Research Article
Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia
Table 4
Distribution of hematological parameters and Hb analysis for each genotype.
| | Genotype | β0 heterozygotes | β+ heterozygotes | | CD 35 (−C) | CD 41–42 (−TCTT) | CD 8/9 (+G) | IVS1-nt1 | IVS1-nt5 | HbE | HbMalay | | n = 3 | n = 14 | n = 4 | n = 16 | n = 59 | n = 35 | n = 47 |
| | Hematological parameter | | Hb (g/dL) | 12.1 (10.8–12.3) | 10.9 (8.8–13.5) | 12.1 (11.1–13.0) | 11.0 (9.4–13.3) | 11.4 (9.3–14.6) | 12.7 (9.5–15.1) | 12.3 (8.3–15.5) | | MCV (fL) | 65.9 (63.3–68.3) | 60.2 (55.6–63.4) | 61.3 (61.1–61.5) | 62.5 (54.4–85.3) | 63.9 (51.9–79.5) | 75.2 (61.9–83.3) | 71.2 (53,4–81,3) | | MCH (pg) | 20.0 (20.0–21.0) | 18.5 (17.0–20.0) | 18.0a | 19.0 (17.0–28.0) | 20.0 (15.0–26.0) | 24.0 (18.0–30.0) | 22.0 (16.0–25.0) | | RDW (%) | 15.6 (14.5–17.7) | 18.0 (15.4–20.8) | 18.2 (17.6–19.1) | 17.5 (12.1–20.1) | 17.2 (12.6–20.2) | 14.6 (12.3–18.3) | 15.6 (13.5–20.6) |
| | Hemoglobin analysis | | HbA2 (%) | 5.4 (5.1–5.4) | 5.5 (4.9–6.6) | 4.8 (4.7–5.3) | 5.2 (2.7–6.1) | 5.0 (1.9–6.4) | 3.7 (2.9–5.7) | 4.5 (3.7–6.0) | | HbF (%) | 0 (0–1.4) | 0.4 (0–2.9) | 0.7 (0–0.4) | 0.7 (0–4.1) | 0 (0–12.7) | 0 (0–24.5) | 0.2 (0–3.9) | | HbA (%) | 94.6 (93.2–94.9) | 93.9 (90.5–95.1) | 95.2 (94.3–95.3) | 93.6 (90.7–96.8) | 94.6 (70.9–98.1) | 71.1 (68.0–94.8) | 95.1 (91.4–96.3) | | HbE (%) (n = 35) | | | | | 1 subject: 25.4 | 25.2 (23.0–27.0) | |
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Abnormal distribution (median). aMCH value in CD 8/9(+G) mutation has the constant value (4 subjects) = 18 pg. |
