Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia

Table 5

Evaluation of different hematological parameters and Hb analysis in the differentiation of β⁰-thalassemia compared to β+-thalassemia.

	Sensitivity	Specificity	PPV (%)	NPV (%)	LR +	LR −	Cutoff for β^0 in our population	AUC (95% CI)
Hematology parameter
Hb	78	56	69	68	1.78	0.39	≤12.3	0.702 (0.625–0.778)
MCV	87	87	89	85	2.71	0.29	≤66.8	0.898 (0.847–0.948)
MCH	85	90	91	83	8.73	0.16	≤20.5	0.900 (0.849–0.952)
MCHC	86	60	73	78	2.14	0.23	≤31.5	0.784 (0.716–0.851)
RDW	79	71	77	73	0.29	2.71	≥16.15	0.211 (0.142–0.280)
Hemoglobin analysis
HbA2	88	74.4	81	84	3.44	0.16	≥4.65	0.844 (0.781–0.906)
HbF	58	61	65	54	1.50	0.68	≥0.35	0.583 (0.500–0.667)

PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; AUC, area under the curve.