Research Article

Associated Factors of Cholelithiasis among Younger Children with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease in Brazzaville, Congo

Table 1

Sociodemographic and clinical characteristics of sickle cell children with and without cholelithiasis and their relationship to cholelithiasis at the National Reference Center for Sickle Cell Disease.

CharacteristicsCholelithiasisWithout cholelithiasisORIC 95%
n(%)n(%)

Gender
 Female2259.43141.9
 Male1540.64358.1
Socioeconomic status
 Low3183.783445.952.381.46–3.89≤0.001
 Middle616.224054.050.070.01–0.52
 High00
Diet
 High in fat38.11000.90.79–1.030.12
 Low in fiber2362.161114.866.820.71–27.18≤0.001
Body mass index
 Normal2875.684256.76
 Underweight612.221722.970.990.83–1.97
 Overweight00.0011.351.140.17–7.400.89
Annual frequency of VOC in the last 3 years
 Mean (min-max)5.43 ± 1.32 (0–20)5.39 ± 1.20 (0–10)
 0–31540.542027.030.850.60–1.200.35
 4 and more2259.465472.971.590.58–4.30
Annual frequency of hospitalization for VOC in the last 3 years
 Mean (min-max)1.97 ± 0.60 (0–6)1.58 ± 0.69 (1–5)
 0–33081.086486.490.990.88–1.120.92
 4 and more718.921013.511.140.08–17.11
Number of blood transfusion since birth
 Mean (min-max)5.54 ± 1.22 (0–20)2.46 ± 1.13 (0–10)
 0–31335.145777.030.30.13–0.67≤0.001
 4 and more2464.861722.973.221.55–6.70
Hydroxyurea treatment
 Yes1232.432533.781.140.51–2.520.75
 No2567.574966.22
Quality of systematic follow-up
 Regular1951.355979.730.540.33–0.88
 Irregular1848.651520.273.411.28–9.040.005

Vasoocclusive crises (pain crises).