Review Article

Rett Syndrome: Coming to Terms with Treatment

Table 1

Rett Syndrome (consensus criteria—2010) (typical or classic).

Regression followed by recovery or stabilization
Must fulfill all main criteria and all exclusion criteria
Supportive criteria while present not required

Main Criteria
Partial or complete loss of purposeful hand skills
Partial or complete loss of spoken language
Gait abnormalities: dyspraxic or absent
Stereotypic hand movements

Exclusion Criteria
Traumatic brain injury
Neurometabolic disease
Severe infection
Very abnormal development in first 6 months of life