Rett Syndrome: Coming to Terms with Treatment

Table 3

Rett syndrome (consensus criteria—2010) (atypical or variant).

Regression followed by recovery or stabilization
Meet at least 3 of 6 main criteria
Meet at least 5 of 11 supportive criteria
Main criteria
Partial or complete loss of purposeful hand skills
Partial or complete loss of spoken language
Gait abnormalities: dyspraxic or absent
Stereotypic hand movements
Supportive criteria
Awake breathing problems	Growth retardation
Bruxism	Small hands and feet
Impaired sleep	Scoliosis and/or kyphosis
Abnormal muscle tone	Increased pain tolerance
Peripheral vasomotor abnormalities	Intense eye contact
Inappropriate laughter or screaming