Research Article
Acute and Subchronic Toxicity Profile of Euphorbia pulcherrima Methanol Extract on Wistar Albino Rats
Table 5
Effect of the E. pulcherrima extract on the serum level of ALAT, ASAT, ALP, T protein, albumin, and bilirubin (liver function parameters) of rats.
| Liver function | Group A | Group B | Group C | Group D | Parameters | (1000 mg/Kg) | (100 mg/Kg) | (10 mg/Kg) | (Control) | Reference value | Mean ± SE | Mean ± SE | Mean ± SE | Mean ± SE |
| ALAT (u/L) (up to 22 UI) | 29.00 ± 1.48 | 32.00 ± 1.67 | 26.00 ± 2.41 | 32.20 ± 2.42 | ASAT (u/L) (up to 218) | 46.20 ± 1.88 | 39.80 ± 4.39 | 48.40 ± 7.42 | 49.80 ± 3.64 | ALP (u/L) (60–170) | 226.60 ± 17.15 | 220.20 ± 7.52 | 206.00 ± 6.50 | 207.00 ± 5.33 | T. Protein (g/L) (58–80) | 80.00 ± 0.71 | 80.80 ± 1.39 | 81.60 ± 0.75 | 83.00 ± 1.34 | T. bilirubin (µmol/L) (1.7–17.1) | 22.00 ± 1.05 | 21.00 ± 0.71 | 20.40 ± 0.60 | 21.40 ± 0.40 | C. bilirubin (µmol /L) (1.7–8.5) | 12.00 ± 0.63 | 11.20 ± 0.66 | 10.80 ± 0.58 | 11.60 ± 0.40 | Albumin (g/L) (35–50 g) | 51.80 ± 1.36 | 51.80 ± 1.07 | 51.00 ± 0.71 | 55.80 ± 2.31 |
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Values are expressed as mean ± SEM for = 5. Values are considered significant if ().
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