The Cold Contact Method as a Simple Drug Interaction Detection System
Figure 3
(a) Cold
contact observation results: (i) the cocrystal grew from clavulanate crystal to
amoxicillin solution in NaOH, (ii) amoxicillin melted at 194ºC, clavulanate
oxidized at 203ºC, while the cocrystal oxidized least. (b) DSC data of
amoxicillin trihydrate (top), potassium clavulanate (middle), and the physical
mixture 1 : 1 (bottom). The exothermic peak of 1 : 1 mixture shows that amoxicillin
and clavulanate overlay and become 1 peak at 202ºC which indicates a solid
solution interaction.
