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Advances in Physical Chemistry
Volume 2011 (2011), Article ID 450912, 15 pages
doi:10.1155/2011/450912
Review Article

Nanotoxicity: Dimensional and Morphological Concerns

Mohmmad Younus Wani,1 Mohd Ali Hashim,2 Firdosa Nabi,3 and Maqsood Ahmad Malik2

1Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia (Central University), New Delhi 110025, India
2Department of Chemical Engineering, University Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Chemistry, University Malaya, 50603 Kuala Lumpur, Malaysia

Received 30 September 2010; Revised 14 December 2010; Accepted 3 January 2011

Academic Editor: Vicki H. Grassian

Copyright © 2011 Mohmmad Younus Wani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Liu, F. Kiessling, and J. Gatjens, “Advanced nanomaterials in multimodal imaging: design, functionalization, and biomedical applications,” Journal of Nanomaterials, vol. 2010, pp. 1–15, 2010.
  2. H. Zeng and S. Sun, “Syntheses, properties, and potential applications of multicomponent magnetic nanoparticles,” Advanced Functional Materials, vol. 18, no. 3, pp. 391–400, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. V. L. Colvin, “The potential environmental impact of engineered nanomaterials,” Nature Biotechnology, vol. 21, no. 10, pp. 1166–1170, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. T. Matsunaga, H. Togo, T. Kikuchi, and T. Tanaka, “Production of luciferase-magnetic particle complex by recombinant Magnetospirillum sp. AMB-1,” Biotechnology and Bioengineering, vol. 70, no. 6, pp. 704–709, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Matsunaga and T. Sakaguchi, “Molecular mechanism of magnet formation in bacteria,” Journal of Bioscience and Bioengineering, vol. 90, no. 1, pp. 1–13, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Oberdörster, E. Oberdörster, and J. Oberdörster, “Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles,” Environmental Health Perspectives, vol. 113, no. 7, pp. 823–839, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Arvidson, “A review of axonal transport of metals,” Toxicology, vol. 88, no. 1–3, pp. 1–14, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. S. E. Cross, B. Innes, M. S. Roberts, T. Tsuzuki, T. A. Robertson, and P. McCormick, “Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation,” Skin Pharmacology and Physiology, vol. 20, no. 3, pp. 148–154, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. B. Nowack and T. D. Bucheli, “Occurrence, behavior and effects of nanoparticles in the environment,” Environmental Pollution, vol. 150, no. 1, pp. 5–22, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. P. H. Hoet, I. Brüske-Hohlfeld, and O. V. Salata, “Nanoparticles—known and unknown health risks,” Journal of Nanobiotechnology, vol. 2, article 12, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. R. Duffin, N. L. Mills, and K. Donaldson, “Nanoparticles—a thoracic toxicology perspective,” Yonsei Medical Journal, vol. 48, no. 4, pp. 561–572, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. J. Aitken, K. S. Creely, and C. L. Tran, “Nanoparticles: an occupational hygiene review,” Institute of Occupational Medicine for the Health and Safety Executive, pp. 1–113, 2004.
  13. H. J. Johnston, G. Hutchison, F. M. Christensen, S. Peters, S. Hankin, and V. Stone, “A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity,” Critical Reviews in Toxicology, vol. 40, no. 4, pp. 328–346, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. S. Brown, K. L. Zeman, and W. D. Bennett, “Ultrafine particle deposition and clearance in the healthy and obstructed lung,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 9, pp. 1240–1247, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. B. J. Marquis, S. A. Love, K. L. Braun, and C. L. Haynes, “Analytical methods to assess nanoparticle toxicity,” Analyst, vol. 134, no. 3, pp. 425–439, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. M. Kulmala, H. Vehkamäki, T. Petäjä et al., “Formation and growth rates of ultrafine atmospheric particles: a review of observations,” Journal of Aerosol Science, vol. 35, no. 2, pp. 143–176, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. M. P. Holsapple, W. H. Farland, T. D. Landry et al., “Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs,” Toxicological Sciences, vol. 88, no. 1, pp. 12–17, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. N. Li, C. Sioutas, A. Cho et al., “Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage,” Environmental Health Perspectives, vol. 111, no. 4, pp. 455–460, 2003. View at Scopus
  19. M. Geiser, B. Rothen-Rutishauser, N. Kapp et al., “Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells,” Environmental Health Perspectives, vol. 113, no. 11, pp. 1555–1560, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Savić, L. Luo, A. Eisenberg, and D. Maysinger, “Micellar nanocontainers distribute to defined cytoplasmic organelles,” Science, vol. 300, no. 5619, pp. 615–618, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. A. Hoshino, K. Fujioka, T. Oku et al., “Quantum dots targeted to the assigned organelle in living cells,” Microbiology and Immunology, vol. 48, no. 12, pp. 985–994, 2004. View at Scopus
  22. V. Salnikov, Y. O. Lukyánenko, C. A. Frederick, W. J. Lederer, and V. Lukyánenko, “Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles,” Biophysical Journal, vol. 92, no. 3, pp. 1058–1071, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. K. Donaldson and V. Stone, “Current hypotheses on the mechanisms of toxicity of ultrafine particles,” Annali dell'Istituto Superiore di Sanita, vol. 39, no. 3, pp. 405–410, 2003. View at Scopus
  24. A. Hett, “Nanotechnology: small matter, many unknowns,” Swiss Re publications, 2004.
  25. G. Oberdörster, A. Maynard, K. Donaldson et al., “Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy,” Particle and Fibre Toxicology, vol. 2, article 8, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. Z. Li, T. Hulderman, R. Salmen et al., “Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes,” Environmental Health Perspectives, vol. 115, no. 3, pp. 377–382, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. K. Donaldson, R. Aitken, L. Tran et al., “Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety,” Toxicological Sciences, vol. 92, no. 1, pp. 5–22, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. K. E. Cha and H. Myung, “Cytotoxic effects of nanoparticles assessed in vitro and in vivo,” Journal of Microbiology and Biotechnology, vol. 17, no. 9, pp. 1573–1578, 2007. View at Scopus
  29. A. Huczko, H. Lange, E. Calko, H. Grubek-Jaworska, and P. Droszcz, “Physiological testing of carbon nanotubes: are they asbestos-like?” Fullerene Science and Technology, vol. 9, no. 2, pp. 251–254, 2001. View at Publisher · View at Google Scholar
  30. C. P. Firme and P. R. Bandaru, “Toxicity issues in the application of carbon nanotubes to biological systems,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 6, no. 2, pp. 245–256, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. P. J. A. Borm and W. Kreyling, “Toxicological hazards of inhaled nanoparticles—potential implications for drug delivery,” Journal of Nanoscience and Nanotechnology, vol. 4, no. 5, pp. 521–531, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. A. A. Shvedova, E. R. Kisin, R. Mercer et al., “Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice,” American Journal of Physiology, vol. 289, no. 5, pp. L698–L708, 2005. View at Publisher · View at Google Scholar · View at PubMed
  33. D. C. Chalupa, P. E. Morrow, G. Oberdörster, M. J. Utell, and M. W. Frampton, “Ultrafine particle deposition in subjects with asthma,” Environmental Health Perspectives, vol. 112, no. 8, pp. 879–882, 2004. View at Scopus
  34. R. D. Handy, T. B. Henry, T. M. Scown, B. D. Johnston, and C. R. Tyler, “Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis,” Ecotoxicology, vol. 17, no. 5, pp. 396–409, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. B. Nowack and T. D. Bucheli, “Occurrence, behavior and effects of nanoparticles in the environment,” Environmental Pollution, vol. 150, no. 1, pp. 5–22, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. N. Lewinski, V. Colvin, and R. Drezek, “Cytotoxicity of nanopartides,” Small, vol. 4, no. 1, pp. 26–49, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. R. F. Service, “Nanotechnology grows up,” Science, vol. 304, no. 5678, pp. 1732–1734, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. G. Oberdörster, E. Oberdörster, and J. Oberdörster, “Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles,” Environmental Health Perspectives, vol. 113, no. 7, pp. 823–839, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. R. D. Handy, R. Owen, and E. Valsami-Jones, “The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs,” Ecotoxicology, vol. 17, no. 5, pp. 315–325, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicology in Vitro, vol. 19, no. 7, pp. 975–983, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. C. M. Sayes, J. D. Fortner, W. Guo et al., “The differential cytotoxicity of water-soluble fullerenes,” Nano Letters, vol. 4, no. 10, pp. 1881–1887, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. G. L. Baker, A. Gupta, M. L. Clark et al., “Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles,” Toxicological Sciences, vol. 101, no. 1, pp. 122–131, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. A. C. P. Elder, R. Gelein, J. N. Finkelstein, C. Cox, and G. Oberdorster, “Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin,” Inhalation Toxicology, vol. 12, no. 4, pp. 227–246, 2000. View at Scopus
  44. E. Oberdörster, “Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass,” Environmental Health Perspectives, vol. 112, no. 10, pp. 1058–1062, 2004. View at Scopus
  45. S. B. Lovern and R. Klaper, “Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles,” Environmental Toxicology and Chemistry, vol. 25, no. 4, pp. 1132–1137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. D. Y. Lyon, L. K. Adams, J. C. Falkner, and P. J. J. Alvarez, “Antibacterial activity of fullerene water suspensions: effects of preparation method and particle size,” Environmental Science and Technology, vol. 40, no. 14, pp. 4360–4366, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Y. Lyon, J. D. Fortner, C. M. Sayes, V. L. Colvin, and J. B. Hughes, “Bacterial cell association and antimicrobial activity of a C60 water suspension,” Environmental Toxicology and Chemistry, vol. 24, no. 11, pp. 2757–2762, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. H. E. Wichmann, C. Spix, T. Tuch et al., “Daily mortality and fine and ultrafine particles in Erfurt, Germany part I: role of particle number and particle mass,” Research Report, no. 98, pp. 5–87, 2000. View at Scopus
  49. A. M. Derfus, W. C. W. Chan, and S. N. Bhatia, “Probing the cytotoxicity of semiconductor quantum dots,” Nano Letters, vol. 4, no. 1, pp. 11–18, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. D. B. Warheit, T. R. Webb, C. M. Sayes, V. L. Colvin, and K. L. Reed, “Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area,” Toxicological Sciences, vol. 91, no. 1, pp. 227–236, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. V. H. Grassian, P. T. O'Shaughnessy, A. Adamcakova-Dodd, J. M. Pettibone, and P. S. Thorne, “Inhalation exposure study of Titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm,” Environmental Health Perspectives, vol. 115, no. 3, pp. 397–402, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. J. M. Pettibone, A. Adamcakova-Dodd, P. S. Thorne, P. T. O'Shaughnessy, J. A. Weydert, and V. H. Grassian, “Inflammatory response of mice following inhalation exposure to iron and copper nanoparticles,” Nanotoxicology, vol. 2, no. 4, pp. 189–204, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Nemmar, M. F. Hoylaerts, P. H. M. Hoet, J. Vermylen, and B. Nemery, “Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis,” Toxicology and Applied Pharmacology, vol. 186, no. 1, pp. 38–45, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. B. Veronesi, C. D. Haar, L. Lee, and M. Oortgiesen, “The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells,” Toxicology and Applied Pharmacology, vol. 178, no. 3, pp. 144–154, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb, “Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats,” Toxicological Sciences, vol. 77, no. 1, pp. 117–125, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  56. G. Oberdörster, J. Ferin, and B. E. Lehnert, “Correlation between particle size, in vivo particle persistence, and lung injury,” Environmental Health Perspectives, vol. 102, no. 5, pp. 173–179, 1994. View at Scopus
  57. M. Geiser, S. Schürch, and P. Gehr, “Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer,” Journal of Applied Physiology, vol. 94, no. 5, pp. 1793–1801, 2003. View at Scopus
  58. D. M. Brown, K. Donaldson, P. J. Borm et al., “Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles,” American Journal of Physiology, vol. 286, no. 2, pp. L344–L353, 2004. View at Scopus
  59. C. S. Hansen, M. Sheykhzade, P. Møller et al., “Diesel exhaust particles induce endothelial dysfunction in apoE−/− mice,” Toxicology and Applied Pharmacology, vol. 219, no. 1, pp. 24–32, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. Z. Li, T. Hulderman, R. Salmen et al., “Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes,” Environmental Health Perspectives, vol. 115, no. 3, pp. 377–382, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. P. P. Simeonova and A. Erdely, “Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers,” Inhalation Toxicology, vol. 21, no. 1, pp. 68–73, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. P. R. Lockman, J. M. Koziara, R. J. Mumper, and D. Allen, “Nanoparticle surface charges alter blood-brain barrier integrity and permeability,” Journal of Drug Targeting, vol. 12, no. 9-10, pp. 635–641, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. Y. Jallouli, A. Paillard, J. Chang, E. Sevin, and D. Betbeder, “Influence of surface charge and inner composition of porous nanoparticles to cross blood-brain barrier in vitro,” International Journal of Pharmaceutics, vol. 344, no. 1-2, pp. 103–109, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  64. T. C. Long, N. Saleh, R. D. Tilton, G. V. Lowry, and B. Veronesi, “Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity,” Environmental Science and Technology, vol. 40, no. 14, pp. 4346–4352, 2006. View at Publisher · View at Google Scholar
  65. A. Peters, B. Veronesi, L. Calderón-Garcidueñas et al., “Translocation and potential neurological effects of fine and ultrafine particles a critical update,” Particle and Fibre Toxicology, vol. 3, article 13, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  66. B. Baroli, M. G. Ennas, F. Loffredo, M. Isola, R. Pinna, and M. A. López-Quintela, “Penetration of metallic nanoparticles in human full-thickness skin,” Journal of Investigative Dermatology, vol. 127, no. 7, pp. 1701–1712, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. A. V. Zvyagin, X. Zhao, A. Gierden, W. Sanchez, J. A. Ross, and M. S. Roberts, “Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo,” Journal of Biomedical Optics, vol. 13, no. 6, Article ID 064031, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. A. Nel, T. Xia, L. Mädler, and N. Li, “Toxic potential of materials at the nanolevel,” Science, vol. 311, no. 5761, pp. 622–627, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. G. G. Xiao, M. Wang, N. Li, J. A. Loo, and A. E. Nel, “Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line,” Journal of Biological Chemistry, vol. 278, no. 50, pp. 50781–50790, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. A. A. Clancy, Y. Gregoriou, K. Yaehne, and D. T. Cramb, “Measuring properties of nanoparticles in embryonic blood vessels: towards a physicochemical basis for nanotoxicity,” Chemical Physics Letters, vol. 488, no. 4-6, pp. 99–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  71. R. D. Holbrook, K. E. Murphy, J. B. Morrow, and K. D. Cole, “Trophic transfer of nanoparticles in a simplified invertebrate food web,” Nature Nanotechnology, vol. 3, no. 6, pp. 352–355, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  72. D. R. Larson, W. R. Zipfel, R. M. Williams et al., “Water-soluble quantum dots for multiphoton fluorescence imaging in vivo,” Science, vol. 300, no. 5624, pp. 1434–1436, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  73. A. M. Smith, S. Dave, S. Nie, L. True, and X. Gao, “Multicolor quantum dots for molecular diagnostics of cancer,” Expert Review of Molecular Diagnostics, vol. 6, no. 2, pp. 231–244, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. K. Kulthong, S. Srisung, K. Boonpavanitchakul, W. Kangwansupamonkon, and R. Maniratanachote, “Determination of silver nanoparticle release from antibacterial fabrics into artificial sweat,” Particle and Fibre Toxicology, vol. 7, article 8, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. J. E. Paddle-Ledinek, Z. Nasa, and H. J. Cleland, “Effect of different wound dressings on cell viability and proliferation,” Plastic and Reconstructive Surgery, vol. 117, no. 7, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. P. K. Lam, E. S. Y. Chan, W. S. Ho, and C. T. Liew, “In vitro cytotoxicity testing of a nanocrystalline silver dressing (Acticoat) on cultured keratinocytes,” British Journal of Biomedical Science, vol. 61, no. 3, pp. 125–127, 2004. View at Scopus
  77. V. K. M. Poon and A. Burd, “In vitro cytotoxity of silver: implication for clinical wound care,” Burns, vol. 30, no. 2, pp. 140–147, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  78. S. Arora, J. Jain, J. M. Rajwade, and K. M. Paknikar, “Cellular responses induced by silver nanoparticles: in vitro studies,” Toxicology Letters, vol. 179, no. 2, pp. 93–100, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  79. S. Arora, J. Jain, J. M. Rajwade, and K. M. Paknikar, “Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells,” Toxicology and Applied Pharmacology, vol. 236, no. 3, pp. 310–318, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. Y. H. Hsin, C. F. Chen, S. Huang, T. S. Shih, P. S. Lai, and P. J. Chueh, “The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells,” Toxicology Letters, vol. 179, no. 3, pp. 130–139, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  81. P. Gopinath, S. K. Gogoi, P. Sanpui, A. Paul, A. Chattopadhyay, and S. S. Ghosh, “Signaling gene cascade in silver nanoparticle induced apoptosis,” Colloids and Surfaces B, vol. 77, no. 2, pp. 240–245, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  82. S. Takenaka, E. Karg, C. Roth et al., “Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats,” Environmental Health Perspectives, vol. 109, no. 4, pp. 547–551, 2001. View at Scopus
  83. J. H. Sung, J. H. Ji, J. U. Yoon et al., “Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles,” Inhalation Toxicology, vol. 20, no. 6, pp. 567–574, 2008. View at Publisher · View at Google Scholar · View at PubMed
  84. S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicology in Vitro, vol. 19, no. 7, pp. 975–983, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  85. K. Kawata, M. Osawa, and S. Okabe, “In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells,” Environmental Science and Technology, vol. 43, no. 15, pp. 6046–6051, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. C. Greulich, S. Kittler, M. Epple, G. Muhr, and M. Köller, “Studies on the biocompatibility and the interaction of silver nanoparticles with human mesenchymal stem cells (hMSCs),” Langenbeck's Archives of Surgery, vol. 394, no. 3, pp. 495–502, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  87. G. Oberdörster, Z. Sharp, V. Atudorei et al., “Translocation of inhaled ultrafine particles to the brain,” Inhalation Toxicology, vol. 16, no. 6-7, pp. 437–445, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. K. Soto, K. M. Garza, and L. E. Murr, “Cytotoxic effects of aggregated nanomaterials,” Acta Biomaterialia, vol. 3, no. 3, pp. 351–358, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  89. C. Carlson, S. M. Hussein, A. M. Schrand et al., “Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species,” Journal of Physical Chemistry B, vol. 112, no. 43, pp. 13608–13619, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  90. L. Braydich-Stolle, S. Hussain, J. J. Schlager, and M. C. Hofmann, “In vitro cytotoxicity of nanoparticles in mammalian germline stem cells,” Toxicological Sciences, vol. 88, no. 2, pp. 412–419, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. M. Ahamed, M. Karns, M. Goodson et al., “DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells,” Toxicology and Applied Pharmacology, vol. 233, no. 3, pp. 404–410, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  92. P. V. Asharani, Y. L. Wu, Z. Gong, and S. Valiyaveettil, “Toxicity of silver nanoparticles in zebrafish models,” Nanotechnology, vol. 19, no. 25, Article ID 255102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  93. R. Foldbjerg, P. Olesen, M. Hougaard, D. A. Dang, H. J. Hoffmann, and H. Autrup, “PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes,” Toxicology Letters, vol. 190, no. 2, pp. 156–162, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  94. F. F. Larese, F. D'Agostin, M. Crosera et al., “Human skin penetration of silver nanoparticles through intact and damaged skin,” Toxicology, vol. 255, no. 1-2, pp. 33–37, 2009. View at Publisher · View at Google Scholar · View at PubMed
  95. M. E. Samberg, S. J. Oldenburg, and N. A. Monteiro-Riviere, “Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro,” Environmental Health Perspectives, vol. 118, no. 3, pp. 407–413, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  96. K. Kalishwaralal, E. Banumathi, S. R. K. Pandian et al., “Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells,” Colloids and Surfaces B, vol. 73, no. 1, pp. 51–57, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  97. A. Elder, R. Gelein, V. Silva et al., “Translocation of inhaled ultrafine manganese oxide particles to the central nervous system,” Environmental Health Perspectives, vol. 114, no. 8, pp. 1172–1178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  98. S. M. Hussain, A. K. Javorina, A. M. Schrand, H. M. H. M. Duhart, S. F. Ali, and J. J. Schlager, “The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion,” Toxicological Sciences, vol. 92, no. 2, pp. 456–463, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  99. V. E. Fako and D. Y. Furgeson, “Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity,” Advanced Drug Delivery Reviews, vol. 61, no. 6, pp. 478–486, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  100. K. J. Lee, P. D. Nallathamby, L. M. Browning, C. J. Osgood, and X. H. Xu, “In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos,” ACS Nano, vol. 1, no. 2, pp. 133–143, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  101. O. Bar-Ilan, R. M. Albrecht, V. E. Fako, and D. Y. Furgeson, “Toxicity assessments of multisized gold and silver nanoparticles in zebrafish embryos,” Small, vol. 5, no. 16, pp. 1897–1910, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  102. J. E. Choi, S. Kim, J. H. Ahn et al., “Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish,” Aquatic Toxicology, vol. 100, pp. 151–159, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  103. Y. Wu, Q. Zhou, H. Li, W. Liu, T. Wang, and G. Jiang, “Effects of silver nanoparticles on the development and histopathology biomarkers of Japanese medaka (Oryzias latipes) using the partial-life test,” Aquatic Toxicology, vol. 100, no. 2, pp. 160–167, 2010. View at Publisher · View at Google Scholar · View at PubMed
  104. Y. J. Chae, C. H. Pham, J. Lee, E. Bae, J. Yi, and M. B. Gu, “Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes),” Aquatic Toxicology, vol. 94, no. 4, pp. 320–327, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  105. J. P. Wise, B. C. Goodale, S. S. Wise et al., “Silver nanospheres are cytotoxic and genotoxic to fish cells,” Aquatic Toxicology, vol. 97, no. 1, pp. 34–41, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  106. K. Bilberg, H. Malte, T. Wang, and E. Baatrup, “Silver nanoparticles and silver nitrate cause respiratory stress in Eurasian perch (Perca fluviatilis),” Aquatic Toxicology, vol. 96, no. 2, pp. 159–165, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  107. T. M. Scown, E. M. Santos, B. D. Johnston et al., “Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout,” Toxicological Sciences, vol. 115, no. 2, pp. 521–534, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  108. G. Laban, L. F. Nies, R. F. Turco, J. W. Bickham, and M. S. Sepúlveda, “The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos,” Ecotoxicology, vol. 19, no. 1, pp. 185–195, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  109. A. H. Ringwood, M. McCarthy, T. C. Bates, and D. L. Carroll, “The effects of silver nanoparticles on oyster embryos,” Marine Environmental Research, vol. 69, pp. S49–S51, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  110. M. Ahamed, R. Posgai, T. J. Gorey, M. Nielsen, S. M. Hussain, and J. J. Rowe, “Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster,” Toxicology and Applied Pharmacology, vol. 242, no. 3, pp. 263–269, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  111. D. J. Benford, A. B. Hanley, K. Bottrill et al., “Biomarkers as predictive tools in toxicity testing,” ATLA Alternatives to Laboratory Animals, vol. 28, no. 1, pp. 119–131, 2000. View at Scopus
  112. E. Bier, “Drosophila, the golden bug, emerges as a tool for human genetics,” Nature Reviews Genetics, vol. 6, no. 1, pp. 9–23, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  113. R. Wasserkort and T. Koller, “Screening toxic effects of volatile organic compounds using Drosophila melanogaster,” Journal of Applied Toxicology, vol. 17, no. 2, pp. 119–125, 1997. View at Publisher · View at Google Scholar · View at Scopus
  114. H. R. Siddique, K. Mitra, V. K. Bajpai, K. Ravi Ram, D. K. Saxena, and D. K. Chowdhuri, “Hazardous effect of tannery solid waste leachates on development and reproduction in Drosophila melanogaster: 70 kDa heat shock protein as a marker of cellular damage,” Ecotoxicology and Environmental Safety, vol. 72, no. 6, pp. 1652–1662, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  115. R. Posgai, M. Ahamed, S. M. Hussain, J. J. Rowe, and M. G. Nielsen, “Inhalation method for delivery of nanoparticles to the Drosophila respiratory system for toxicity testing,” Science of the Total Environment, vol. 408, no. 2, pp. 439–443, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  116. S. C. Gupta, A. Sharma, M. Mishra, R. K. Mishra, and D. K. Chowdhuri, “Heat shock proteins in toxicology: how close and how far?” Life Sciences, vol. 86, no. 11-12, pp. 377–384, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  117. J. Y. Roh, J. S. Sang, J. Yi et al., “Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics,” Environmental Science and Technology, vol. 43, no. 10, pp. 3933–3940, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. J. H. Sung, J. H. Ji, J. U. Yoon et al., “Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles,” Inhalation Toxicology, vol. 20, no. 6, pp. 567–574, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  119. Y. S. Kim, J. S. Kim, H. S. Cho et al., “Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats,” Inhalation Toxicology, vol. 20, no. 6, pp. 575–583, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  120. M. L. Schipper, N. Nakayama-Ratchford, C. R. Davis et al., “A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice,” Nature Nanotechnology, vol. 3, no. 4, pp. 216–221, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  121. Z. Liu, K. Chen, C. Davis et al., “Drug delivery with carbon nanotubes for in vivo cancer treatment,” Cancer Research, vol. 68, no. 16, pp. 6652–6660, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  122. A. Huczko and H. Lange, “Carbon nanotubes: experimental evidence for a null risk of skin irritation and allergy,” Fullerene Science and Technology, vol. 9, no. 2, pp. 247–250, 2001. View at Publisher · View at Google Scholar · View at Scopus
  123. C.-W. Lam, J. T. James, R. McCluskey, and R. L. Hunter, “Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intractracheal instillation,” Toxicological Sciences, vol. 77, no. 1, pp. 126–134, 2004. View at Publisher · View at Google Scholar · View at PubMed
  124. D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb, “Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats,” Toxicological Sciences, vol. 77, no. 1, pp. 117–125, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  125. A. A. Shvedova, E. R. Kisin, R. Mercer et al., “Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice,” American Journal of Physiology, vol. 289, no. 5, pp. L698–L708, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  126. P. Cherukuri, C. J. Gannon, T. K. Leeuw et al., “Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 50, pp. 18882–18886, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  127. M. Davoren, E. Herzog, A. Casey et al., “In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells,” Toxicology in Vitro, vol. 21, no. 3, pp. 438–448, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  128. K. Pulskamp, S. Diabaté, and H. F. Krug, “Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants,” Toxicology Letters, vol. 168, no. 1, pp. 58–74, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  129. W. Lin, Y. W. Huang, X. D. Zhou, and Y. Ma, “In vitro toxicity of silica nanoparticles in human lung cancer cells,” Toxicology and Applied Pharmacology, vol. 217, no. 3, pp. 252–259, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  130. J.-S. Chang, K. L.B. Chang, D.-F. Hwang, and Z.-L. Kong, “In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line,” Environmental Science and Technology, vol. 41, no. 6, pp. 2064–2068, 2007. View at Publisher · View at Google Scholar
  131. Y. Jin, S. Kannan, M. Wu, and J. X. Zhao, “Toxicity of luminescent silica nanoparticles to living cells,” Chemical Research in Toxicology, vol. 20, no. 8, pp. 1126–1133, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  132. T. K. Barik, B. Sahu, and V. Swain, “Nanosilica—from medicine to pest control,” Parasitology Research, vol. 103, no. 2, pp. 253–258, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  133. H. Yang, C. Liu, D. Yang, H. Zhang, and Z. Xi, “Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition,” Journal of Applied Toxicology, vol. 29, no. 1, pp. 69–78, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  134. M. Chen and A. von Mikecz, “Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles,” Experimental Cell Research, vol. 305, no. 1, pp. 51–62, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  135. F. Wang, F. Gao, M. Lan, H. Yuan, Y. Huang, and J. Liu, “Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells,” Toxicology in Vitro, vol. 23, no. 5, pp. 808–815, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  136. W. Lin, Y. W. Huang, X. D. Zhou, and Y. Ma, “In vitro toxicity of silica nanoparticles in human lung cancer cells,” Toxicology and Applied Pharmacology, vol. 217, no. 3, pp. 252–259, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  137. D. Lison, L. C. J. Thomassen, V. Rabolli et al., “Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays,” Toxicological Sciences, vol. 104, no. 1, pp. 155–162, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  138. E. J. Park and K. Park, “Oxidative stress and proinflammatory responses induced by silica nanoparticles in vivo and in vitro,” Toxicology Letters, vol. 184, no. 1, pp. 18–25, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  139. I. Bremner, “Manifestations of copper excess,” American Journal of Clinical Nutrition, vol. 67, no. 5, 1998. View at Scopus
  140. D. R. Winge and R. K. Mehra, “Host defenses against copper toxicity,” International Review of Experimental Pathology, vol. 31, pp. 47–83, 1990. View at Scopus
  141. D. G. Barceloux, “Copper,” Journal Toxicological Clinical Toxicology, vol. 37, no. 2, pp. 217–230, 1999. View at Publisher · View at Google Scholar · View at Scopus
  142. G. Liu, X. Li, B. Qin, D. Xing, Y. Guo, and R. Fan, “Investigation of the mending effect and mechanism of copper nano-particles on a tribologically stressed surface,” Tribology Letters, vol. 17, no. 4, pp. 961–966, 2004. View at Publisher · View at Google Scholar · View at Scopus
  143. N. Cioffi, N. Ditaranto, L. Torsi et al., “Analytical characterization of bioactive fluoropolymer ultra-thin coatings modified by copper nanoparticles,” Analytical and Bioanalytical Chemistry, vol. 381, no. 3, pp. 607–616, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  144. V. N. Bakunin, A. YU. Suslov, G. N. Kuzmina, and O. P. Parenago, “Synthesis and application of inorganic nanoparticles as lubricant components-a review,” Journal of Nanoparticle Research, vol. 6, no. 2-3, pp. 273–284, 2004. View at Scopus
  145. K. Guo, Q. Pan, L. Wang, and S. Fang, “Nano-scale copper-coated graphite as anode material for lithium-ion batteries,” Journal of Applied Electrochemistry, vol. 32, no. 6, pp. 679–685, 2002. View at Publisher · View at Google Scholar · View at Scopus
  146. H. Meng, Z. Chen, G. Xing et al., “Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles,” Toxicology Letters, vol. 175, no. 1–3, pp. 102–110, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  147. Z. Chen, H. Meng, G. Xing et al., “Acute toxicological effects of copper nanoparticles in vivo,” Toxicology Letters, vol. 163, no. 2, pp. 109–120, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  148. C. M. Galhardi, Y. S. Diniz, L. A. Faine et al., “Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction,” Food and Chemical Toxicology, vol. 42, no. 12, pp. 2053–2060, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  149. R. Lei, C. Wu, and B. Yang, “Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid in vivoscreening method for nanotoxicity,” Toxicology and Applied Pharmacology, vol. 232, no. 2, 2008.
  150. M. Prato, “Fullerene chemistry for materials science applications,” Journal of Materials Chemistry, vol. 7, no. 7, pp. 1097–1109, 1997. View at Scopus
  151. D. Heymann, “Solubility of fullerenes C60 and C70 in seven normal alcohols and their deduced solubility in water,” Fullerene Science and Technology, vol. 4, no. 3, pp. 509–515, 1996. View at Scopus
  152. X. Cheng, A. T. Kan, and M. B. Tomson, “Naphthalene adsorption and desorption from aqueous C60 fullerene,” Journal of Chemical and Engineering Data, vol. 49, no. 3, pp. 675–683, 2004. View at Publisher · View at Google Scholar · View at Scopus
  153. J. D. Fortner, D. Y. Lyon, C. M. Sayes et al., “C60 in water: nanocrystal formation and microbial response,” Environmental Science and Technology, vol. 39, no. 11, pp. 4307–4316, 2005. View at Publisher · View at Google Scholar · View at Scopus
  154. D. Y. Lyon and P. J. J. Alvarez, “Fullerene water suspension (nC60) exerts antibacterial effects via ROS-independent protein oxidation,” Environmental Science and Technology, vol. 42, no. 21, pp. 8127–8132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  155. S. B. Lovern and R. Klaper, “Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles,” Environmental Toxicology and Chemistry, vol. 25, no. 4, pp. 1132–1137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  156. S. Zhu, E. Oberdörster, and M. L. Haasch, “Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow,” Marine Environmental Research, vol. 62, no. 1, pp. S5–S9, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  157. A. Dhawan, J. S. Taurozzi, A. K. Pandey et al., “Stable colloidal dispersions of C60 fullerenes in water: evidence for genotoxicity,” Environmental Science and Technology, vol. 40, no. 23, pp. 7394–7401, 2006. View at Publisher · View at Google Scholar · View at Scopus
  158. K.-T. Kim, M.-H. Jang, J.-Y. Kim, and S. D. Kim, “Effect of preparation methods on toxicity of fullerene water suspensions to Japanese medaka embryos,” Science of the Total Environment, vol. 408, no. 22, pp. 5606–5612, 2010. View at Publisher · View at Google Scholar · View at PubMed
  159. P. Hoet and J. Boczkowski, “What's new in nanotoxicology? Brief review of the 2007 literature,” Nanotoxicology, vol. 2, no. 3, pp. 171–182, 2008. View at Publisher · View at Google Scholar · View at Scopus
  160. R. F. Service, “Nanotechnology grows up,” Science, vol. 304, no. 5678, pp. 1732–1734, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  161. M. R. Gwinn and V. Vallyathan, “Nanoparticles: health effects—pros and cons,” Environmental Health Perspectives, vol. 114, no. 12, pp. 1818–1825, 2006. View at Publisher · View at Google Scholar · View at Scopus
  162. J. K. Nicholson, J. Connelly, J. C. Lindon, and E. Holmes, “Metabonomics: a platform for studying drug toxicity and gene function,” Nature Reviews Drug Discovery, vol. 1, no. 2, pp. 153–161, 2002. View at Publisher · View at Google Scholar · View at Scopus
  163. H. J. Atherton, N. J. Bailey, W. Zhang et al., “A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-α null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome,” Physiological Genomics, vol. 27, no. 2, pp. 178–186, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  164. E. J. Want, A. Nordström, H. Morita, and G. Siuzdak, “From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics,” Journal of Proteome Research, vol. 6, no. 2, pp. 459–468, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  165. M. L. Anthony, K. P. R. Gartland, C. R. Beddell, J. C. Lindon, and J. K. Nicholson, “Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage,” Archives of Toxicology, vol. 66, no. 8, pp. 525–537, 1992. View at Publisher · View at Google Scholar · View at Scopus
  166. K. P. R. Gartland, C. R. Beddell, J. C. Lindon, and J. K. Nicholson, “Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine,” Molecular Pharmacology, vol. 39, no. 5, pp. 629–642, 1991.
  167. E. Holmes, A. W. Nicholls, J. C. Lindon et al., “Chemometric models for toxicity classification based on NMR spectra of biofluids,” Chemical Research in Toxicology, vol. 13, no. 6, pp. 471–478, 2000. View at Publisher · View at Google Scholar · View at Scopus
  168. C. J. Waterfield, J. A. Turton, M. D. C. Scales, and J. A. Timbrell, “Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats,” Archives of Toxicology, vol. 67, no. 4, pp. 244–254, 1993. View at Scopus
  169. D. G. Robertson, M. D. Reily, R. E. Sigler, D. F. Wells, D. A. Paterson, and T. K. Braden, “Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants,” Toxicological Sciences, vol. 57, no. 2, pp. 326–337, 2000. View at Scopus
  170. N. J. Waters, C. J. Waterfield, R. D. Farrant, E. Holmes, and J. K. Nicholson, “Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis,” Journal of Proteome Research, vol. 5, no. 6, pp. 1448–1459, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  171. S. Parvez, C. Venkataraman, and S. Mukherji, “A review on advantages of implementing luminescence inhibition test (Vibrio fischeri) for acute toxicity prediction of chemicals,” Environment International, vol. 32, no. 2, pp. 265–268, 2006. View at Publisher · View at Google Scholar · View at PubMed
  172. A. P. Loibner, O. H. J. Szolar, R. Braun, and D. Hirmann, “Toxicity testing of 16 priority polycyclic aromatic hydrocarbons using Lumistox,” Environmental Toxicology and Chemistry, vol. 23, no. 3, pp. 557–564, 2004. View at Publisher · View at Google Scholar · View at Scopus
  173. J. Lappalainen, R. Juvonen, J. Nurmi, and M. Karp, “Automated color correction method for Vibrio fischeri toxicity test. Comparison of standard and kinetic assays,” Chemosphere, vol. 45, no. 4-5, pp. 635–641, 2001. View at Publisher · View at Google Scholar · View at Scopus
  174. H. Zheng, L. Liu, Y. Lu et al., “Rapid determination of nanotoxicity using luminous bacteria,” Analytical Sciences, vol. 26, no. 1, pp. 125–128, 2010. View at Publisher · View at Google Scholar · View at Scopus