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Advances in Physical Chemistry
Volume 2014 (2014), Article ID 238984, 8 pages
http://dx.doi.org/10.1155/2014/238984
Research Article

Oxidation of Tetracaine Hydrochloride by Chloramine-B in Acid Medium: Kinetic Modeling

1Department of Chemistry, Don Bosco Institute of Technology, Kumbalagodu, Bangalore 560 074, India
2Department of Chemistry, Bangalore University, Central College, Bangalore 560 001, India

Received 20 August 2013; Revised 22 October 2013; Accepted 5 November 2013; Published 10 February 2014

Academic Editor: Francesco Paolucci

Copyright © 2014 Jayachamarajapura Pranesh Shubha and Puttaswamy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tetracaine hydrochloride (TCH) is one of the potent local anaesthetics. A kinetic study of oxidation of tetracaine hydrochloride by sodium N-chlorobenzenesulfonamide (chloramine-B or CAB) has been carried in HClO4 medium at 303 K. The rate shows first-order dependence on , shows fractional–order dependence on , and is self-governing on acid concentration. Decrease of dielectric constant of the medium, by adding methanol, increased the rate. Variation of ionic strength and addition of benzenesulfonamide or NaCl have no significant effect on the rate. The reaction was studied at different temperatures and the activation parameters have been evaluated. The stoichiometry of the reaction was found to be 1 : 5 and the oxidation products were identified by spectral analysis. The conjugate free acid C6H5SO2NHCl of CAB is postulated as the reactive oxidizing species. The observed results have been explained by plausible mechanism and the related rate law has been deduced.