Organic Compounds Based on (E)-N-Aryl-2-ethene-sulfonamide as Microtubule Targeted Agents in Prostate Cancer: QSAR Study

Table 5

The correlation matrix (Pearson ()) between different obtained descriptors.

Desc	MD	Rep	MW	HA	HD		polarb	density	surf ten	parac	MR	Ind	MV
MD	1
Rep		1
MW		0.958	1
HA		0.384		1
HD		0.476			1
		0.212				1
polrb		0.813				0.124	1
density		0.228				0.532	−0.241	1
surf tn		0.196				0.174	0.492		1
parac		0.856				0.063	0.989		0.391	1
MR		0.813				0.124	1.000		0.492	0.989	1
Ind		0.096				0.257	0.470		0.959	0.347	0.470	1
MV		0.864				0.012	0.937		0.174	0.974	0.937	0.136	1
		0.320					0.652		0.443	0.647	0.653	0.386	0.587	1
							0.351		0.488	0.285	0.351	0.539	0.182	0.697	1
																1

Polarizability and parachoc are perfectly correlated (); polarizability and MR are perfectly correlated (); parachor and MR are perfectly correlated (). Both variables are redundant; parachoc and MV are perfectly correlated (). Therefore, it is necessary to remove all the correlated variables such as parachoc and MR.