Table 3: Absolute and percent change in lipid parameters from baseline to 6 weeks and from baseline to 12 weeks, by treatment group.

ParameterEZE + StatinSTAT2 Value
(Between-Group)


Six weeks, mmol/L (mean ± SD)
 Total cholesterolAbsolute change * *0.600
% change * *0.469
 LDL-C Absolute change * *0.494
% change * *0.378
 HDL-C Absolute change 0.602
% change 0.575
 TriglyceridesAbsolute change 0.152
% change 0.253
 Total Chol/HDL-CAbsolute change * 0.708
% change * 0.341


Twelve weeks, mmol/L (mean ± SD)**
 Total cholesterolAbsolute change * *0.917
% change * *0.741
 LDL-C Absolute change * *0.830
% change * *0.517
 HDL-C Absolute change 0.257
% change 0.960
 Triglycerides Absolute change * 0.141
% change * 0.084
 Total Chol/HDL-C Absolute change * 0.757
% change * *0.220


Twelve weeks sensitivity analysis,
mmol/L (mean ± SD)***
 Total cholesterol Absolute change * *0.810
% change * *0.874
 LDL-C Absolute change * *0.197
% change * *0.170
 HDL-C Absolute change 0.761
% change 0.864
 Triglycerides Absolute change * 0.559
% change 0.961
 Total Chol/HDL-C Absolute change * 0.125
% change * *0.207

LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol
* value based on One-Sample t-test (significantly different than zero). Alpha level of 0.025 to account for multiple comparisons
**12 weeks results account for 2 crossovers in treatment assignment, reflecting treatment actually received (Figure 2)
***12 weeks sensitivity analysis excluded the 2 crossovers and was conducted only on patients maintained in their respective treatment group.