Advanced Development of the rF1V and rBV A/B Vaccines: Progress and Challenges

Table 2

Symptoms following aerosol exposure to BoNT/A1 or BoNT/B1.

Symptoms	Human^1	NHP; (rhesus macaque)	Guinea pig; (Hartley)	Mouse; (CD-1)	NHP; (rhesus macaque)	Guinea pig; (Hartley)	Mouse; (CD-1)
		Inhalational BoNT/A1			Inhalational BoNT/B1
Onset of symptoms: dose dependent	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Lethargy	Yes^1	Yes	Yes	NR	Yes	Yes	NR
Flaccid paralysis	Yes	NR	Yes	Yes	NR	NR	Yes
Ptosis (drooping eyelids)	Yes	Yes	Yes	Yes	Yes	Yes	No
Dysphagia (difficulty swallowing)	Yes^1	Yes	NR	NR	Yes	NR	NR
Symmetric, descending paralysis	Yes	Yes	NR	Yes	Yes	NR	NR
Labored respirations	NR^2	Yes	Yes	Yes	Yes	Yes	Yes
Ataxia	Yes^1	Yes	NR	NR	Yes	NR	NR
Muscle weakness	Yes^1	Yes	Yes	Yes	Yes	Yes	Yes
Lateral recumbency	NR	Yes	NR	NR	Yes	NR	NR
Nasal discharge	No	Yes	No?	NR	Yes	Yes	No
Constipation	Yes	Yes	NR	NR	NR	NR	NR
Paresis	Yes	Yes	Yes	Yes	Yes	Yes	NR
Coughing	No	Yes	NR	NR	Yes	No	NR
Piloerection	NR	NR	Yes	Yes	NR	Yes	Yes
Lethality	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Time to death: dose dependent	NR	Yes	Yes	Yes	NR	NR	NR

¹Specific observations in humans following inhalational exposure.
²NR, not reported.