Advances in Pharmacological Sciences
Volume 2009 (2009), Article ID 405107, 11 pages
doi:10.1155/2009/405107
Research Article
Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study
O. Malkesman,
1,2 T. Asaf,
1,2 L. Shbiro,
2,3 A. Goldstein,
2,3 R. Maayan,
4 A. Weizman,
4 N. Kinor,
2,5 E. Okun,
5 B. Sredni,
5 G. Yadid,
2,5 and
A. Weller2,3
1Interdisciplinary Program in the Brain Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
2The Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel
3Department of Psychology, Bar-Ilan University, Ramat-Gan 52900, Israel
4Biological Psychiatry Laboratory, Felsenstein Medical Research Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel
5Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
Received 9 February 2009; Revised 8 June 2009; Accepted 24 July 2009
Academic Editor: Alison Oliveto
Copyright © 2009 O. Malkesman et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- S. K. Bhatia and S. C. Bhatia, “Childhood and adolescent depression,” American Family Physician, vol. 75, no. 1, pp. 73–80, 2007.
- G. Zalsman, D. A. Brent, and V. R. Weersing, “Depressive disorders in childhood and adolescence: an overview. epidemiology, clinical manifestation and risk factors,” Child and Adolescent Psychiatric Clinics of North America, vol. 15, no. 4, pp. 827–841, 2006. View at Publisher · View at Google Scholar · View at PubMed
- M. Kovacs, “Presentation and course of major depressive disorder during childhood and later years of the life span,” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 35, no. 6, pp. 705–715, 1996. View at Publisher · View at Google Scholar
- J. Kaufman, A. Martin, R. A. King, and D. Charney, “Are child-, adolescent-, and adult-onset depression one and the same disorder?” Biological Psychiatry, vol. 49, no. 12, pp. 980–1001, 2001. View at Publisher · View at Google Scholar
- J. Kaufman and N. Ryan, “The neurobiology of child and adolescent depression,” in The Neurobiological Foundation of Mental Illness, D. Charney, E. Nestler, and B. Bunny, Eds., pp. 810–822, Oxford University Press, New York, NY, USA, 1999.
- M. B. Keller, N. D. Ryan, M. Strober, et al., “Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial,” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 40, no. 7, pp. 762–772, 2001.
- B. Birmaher, N. D. Ryan, D. E. Williamson, et al., “Childhood and adolescent depression: a review of the past 10 years,” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 35, no. 11, pp. 1427–1439, 1996. View at Publisher · View at Google Scholar
- T. A. Hammad, T. Laughren, and J. Racoosin, “Suicidality in pediatric patients treated with antidepressant drugs,” Archives of General Psychiatry, vol. 63, no. 3, pp. 332–339, 2006. View at Publisher · View at Google Scholar · View at PubMed
- D. A. Axelson and B. Birmaher, “Relation between anxiety and depressive disorders in childhood and adolescence,” Depression and Anxiety, vol. 14, no. 2, pp. 67–78, 2001. View at Publisher · View at Google Scholar · View at PubMed
- O. Malkesman, Y. Braw, O. Zagoory-Sharon, et al., “Reward and anxiety in genetic animal models of childhood depression,” Behavioural Brain Research, vol. 164, no. 1, pp. 1–10, 2005. View at Publisher · View at Google Scholar · View at PubMed
- O. Malkesman, Y. Braw, R. Maayan, et al., “Two different putative genetic animal models of childhood depression,” Biological Psychiatry, vol. 59, no. 1, pp. 17–23, 2006. View at Publisher · View at Google Scholar · View at PubMed
- O. Malkesman, M. Shayit, R. Genud, et al., “Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: a study in an animal model of childhood depression,” Neuroscience, vol. 149, no. 3, pp. 573–581, 2007. View at Publisher · View at Google Scholar · View at PubMed
- Y. Braw, O. Malkesman, A. Merlender, et al., “Stress hormones and emotion-regulation in two genetic animal models of depression,” Psychoneuroendocrinology, vol. 31, no. 9, pp. 1105–1116, 2006. View at Publisher · View at Google Scholar · View at PubMed
- Y. Braw, O. Malkesman, A. Merenlender, et al., “Withdrawal emotional-regulation in infant rats from genetic animal models of depression,” Behavioural Brain Research, vol. 193, no. 1, pp. 94–100, 2008. View at Publisher · View at Google Scholar · View at PubMed
- B. Birmaher, D. E. Williamson, R. E. Dahl, et al., “Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 43, no. 1, pp. 63–70, 2004. View at Publisher · View at Google Scholar
- C. Touma, T. Fenzl, J. Ruschel, et al., “Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression,” PLoS ONE, vol. 4, no. 1, p. e4325, 2009. View at Publisher · View at Google Scholar · View at PubMed
- P. Willner, “Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation,” Psychopharmacology, vol. 134, no. 4, pp. 319–329, 1997. View at Publisher · View at Google Scholar
- [APA2000] American Psychiatric Association, Ed., Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, Washington, DC, USA, 4th edition, 2000.
- S. M. Stahl, Essential Psychopharmacology of Depression and Bipolar Disorder, Cambridge University Press, Chicago, Ill, USA, 2001.
- G. Piñeyro and P. Blier, “Autoregulation of serotonin neurons: role in antidepressant drug action,” Pharmacological Reviews, vol. 51, no. 3, pp. 533–591, 1999.
- V. A. Vaidya and R. S. Duman, “Depresssion-emerging insights from neurobiology,” British Medical Bulletin, vol. 57, pp. 61–79, 2001.
- N. Maninger, O. M. Wolkowitz, V. I. Reus, E. S. Epel, and S. H. Mellon, “Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS),” Frontiers in Neuroendocrinology, vol. 30, no. 1, pp. 65–91, 2009. View at Publisher · View at Google Scholar · View at PubMed
- P. J. Schmidt, R. C. Daly, M. Bloch, et al., “Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression,” Archives of General Psychiatry, vol. 62, no. 2, pp. 154–162, 2005. View at Publisher · View at Google Scholar · View at PubMed
- R. D. Strous, R. Maayan, and A. Weizman, “The relevance of neurosteroids to clinical psychiatry: from the laboratory to the bedside,” European Neuropsychopharmacology, vol. 16, no. 3, pp. 155–169, 2006. View at Publisher · View at Google Scholar · View at PubMed
- T. Maurice, A. Urani, V.-L. Phan, and P. Romieu, “The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities,” Brain Research Reviews, vol. 37, no. 1–3, pp. 116–132, 2001. View at Publisher · View at Google Scholar
- P. Golubchik, M. Lewis, R. Maayan, J. Sever, R. Strous, and A. Weizman, “Neurosteroids in child and adolescent psychopathology,” European Neuropsychopharmacology, vol. 17, no. 3, pp. 157–164, 2007. View at Publisher · View at Google Scholar · View at PubMed
- N. A. Compagnone and S. H. Mellon, “Dehydroepiandrosterone: a potential signaling molecule for neocortical organization during development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, pp. 4678–4683, 1998.
- E. J. Nestler, M. Barrot, R. J. DiLeone, A. J. Eisch, S. J. Gold, and L. M. Monteggia, “Neurobiology of depression,” Neuron, vol. 34, no. 1, pp. 13–25, 2002. View at Publisher · View at Google Scholar
- K. Martinowich, H. Manji, and B. Lu, “New insights into BDNF function in depression and anxiety,” Nature Neuroscience, vol. 10, no. 9, pp. 1089–1093, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. O. Groves, “Is it time to reassess the BDNF hypothesis of depression?” Molecular Psychiatry, vol. 12, no. 12, pp. 1079–1088, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. S. Duman, “Synaptic plasticity and mood disorders,” Molecular Psychiatry, vol. 7, supplement 1, pp. S29–S34, 2002. View at Publisher · View at Google Scholar
- M. A. Smith, S. Makino, R. Kvetnansky, and R. M. Post, “Stress and glucocorticoids affect the expressing of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus,” Journal of Neuroscience, vol. 15, pp. 1768–1777, 1995.
- Y. Shirayama, A. C. H. Chen, S. Nakagawa, D. S. Russell, and R. S. Duman, “Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression,” Journal of Neuroscience, vol. 22, no. 8, pp. 3251–3261, 2002.
- K. Martinowich and B. Lu, “Interaction between BDNF and serotonin: role in mood disorders,” Neuropsychopharmacology, vol. 33, no. 1, pp. 73–83, 2008. View at Publisher · View at Google Scholar · View at PubMed
- C. R. McKittrick, A. M. Magarinos, D. C. Blanchard, R. J. Blanchard, B. S. McEwen, and R. R. Sakai, “Chronic social stress reduces dendritic arbors in CA3 of hippocampus and decreases binding to serotonin transporter sites,” Synapse, vol. 36, no. 2, pp. 85–94, 2000. View at Publisher · View at Google Scholar
- E. Gould, P. Tanapat, B. S. McEwen, G. Flügge, and E. Fuchs, “Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 6, pp. 3168–3171, 1998. View at Publisher · View at Google Scholar
- E. J. Nestler and W. A. Carlezon Jr., “The mesolimbic dopamine reward circuit in depression,” Biological Psychiatry, vol. 59, no. 12, pp. 1151–1159, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. D. Porsolt, A. Bertin, and M. Jalfre, “Behavioral despair in mice: a primary screening test for antidepressants,” Archives Internationales de Pharmacodynamie et de Therapie, vol. 229, no. 2, pp. 327–336, 1977.
- E. L. Abel, “Ontogeny of immobility and response to alarm substance in the forced swim test,” Physiology & Behavior, vol. 54, no. 4, pp. 713–716, 1993. View at Publisher · View at Google Scholar
- K. Kawashima, H. Araki, and H. Aihara, “Effect of chronic administration of antidepressants on duration of immobility in rats forced to swim,” Japanese Journal of Pharmacology, vol. 40, no. 2, pp. 199–204, 1986.
- E. L. Abel and P. J. Bilitzke, “A possible alarm substance in the forced swim test,” Psychoneuroendocrinology, vol. 17, pp. 255–259, 1990.
- H. Nishimura, A. Tsuda, M. Oguchi, Y. Ida, and M. Tanaka, “Is immobility of rats in the forced swim test “behavioral despair?”,” Physiology & Behavior, vol. 42, no. 1, pp. 93–95, 1988.
- D. H. Overstreet, “The flinders sensitive line rats: a genetic animal model of depression,” Neuroscience and Biobehavioral Reviews, vol. 17, no. 1, pp. 51–68, 1993.
- G. Yadid, R. Nakash, I. Deri, et al., “Elucidation of the neurobiology of depression: insights from a novel genetic animal model,” Progress in Neurobiology, vol. 62, no. 4, pp. 353–378, 2000. View at Publisher · View at Google Scholar
- A. Friedman, E. Dremencov, H. Crown, et al., “Variability of the mesolimbic neuronal activity in a rat model of depression,” NeuroReport, vol. 16, no. 5, pp. 513–516, 2005. View at Publisher · View at Google Scholar
- A. Friedman, Y. Friedman, E. Dermencov, and G. Yadid, “VTA dopamine neuron vursting bursting is altered in animal model of depression and corrected by desipramine,” Journal of Molecular Neuroscience, vol. 34, pp. 201–209, 2008.
- A. Gadek-Michalska and J. Bugajski, “Repeated handling, restraint, or chronic crowding impair the hypothalamic-pituitary-adrenocortical response to acute restraint stress,” Journal of Physiology and Pharmacology, vol. 54, no. 3, pp. 449–459, 2003.
- J. J. Radley, A. B. Rocher, M. Miller, et al., “Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex,” Cerebral Cortex, vol. 16, no. 3, pp. 313–320, 2006. View at Publisher · View at Google Scholar · View at PubMed
- S. M. Brown, S. Henning, and C. L. Wellman, “Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex,” Cerebral Cortex, vol. 15, no. 11, pp. 1714–1722, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. Levine, “Primary social relationships influence the development of the hypothalamic-pituitary-adrenal axis in the rat,” Physiology & Behavior, vol. 73, no. 3, pp. 255–260, 2001. View at Publisher · View at Google Scholar
- J. Panksepp, Affective Neuroscience. The Foundations of Human and Animal Emotions, Oxford University Press, Oxford, NY, USA, 1998.
- E. Dremencov, M. E. Newman, N. Kinor, et al., “Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment,” Neuropharmacology, vol. 48, no. 1, pp. 34–42, 2005. View at Publisher · View at Google Scholar · View at PubMed
- R. Maayan, O. Morad, P. Dorfman, D. H. Overstreet, A. Weizman, and G. Yadid, “The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression,” European Neuropsychopharmacology, vol. 15, pp. 253–262, 2005.
- Y. A. Barde, D. Edgar, and H. Thoenen, “Purification of a new neurotophic factor from mammalian brain,” The European Molecular Biology Organization Journal, vol. 1, pp. 549–553, 1982.
- M. Durand, S. Aguerre, F. Fernandez, et al., “Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in Spontaneously Hypertensive and Wistar-Kyoto rats,” Neuropharmacology, vol. 39, no. 12, pp. 2464–2477, 2000. View at Publisher · View at Google Scholar
- S. Tejani-Butt, J. Kluczynski, and W. P. Paré, “Strain-dependent modification of behavior following antidepressant treatment,” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 27, no. 1, pp. 7–14, 2003. View at Publisher · View at Google Scholar
- C. C. Will, F. Aird, and E. E. Redei, “Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants,” Molecular Psychiatry, vol. 8, no. 11, pp. 925–932, 2003. View at Publisher · View at Google Scholar · View at PubMed
- A. Dranovsky and R. Hen, “Hippocampal neurogenesis: regulation by stress and antidepressants,” Biological Psychiatry, vol. 59, no. 12, pp. 1136–1143, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. S. Duman and L. M. Monteggia, “A neurotrophic model for stress-related mood disorders,” Biological Psychiatry, vol. 59, no. 12, pp. 1116–1127, 2006. View at Publisher · View at Google Scholar · View at PubMed
- F. Svec and J. Porter, “The effect of dehydroepiandrosterone (DHEA) on Zucker rat food selection and hypothalamic neurotransmitters,” Psychoneuroendocrinology, vol. 22, pp. S57–S62, 1997.
- F. P. Monnet, V. Mahe, P. Robel, and E.-E. Baulieu, “Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 9, pp. 3774–3778, 1995.
- M. D. Majewska, S. Demirgoren, C. E. Spivak, and E. D. London, “The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor,” Brain Research, vol. 526, no. 1, pp. 143–146, 1990. View at Publisher · View at Google Scholar
- A. Urani, F. J. Roman, V.-L. Phan, T.-P. Su, and T. Maurice, “The antidepressant-like effect induced by sigma1-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test,” Journal of Pharmacology & Experimental Therapeutics, vol. 298, no. 3, pp. 1269–1279, 2001.
- J. E. Bermack and G. Debonnel, “Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands,” British Journal of Pharmacology, vol. 134, no. 3, pp. 691–699, 2001.
- G. Skuza, “Potential antidepressant activity of sigma ligands,” Polish Journal of Pharmacology, vol. 55, no. 6, pp. 923–934, 2003.
- E. Mignot, A. Seffano, D. Laude, J. L. Elghozi, J. Dedek, and B. Scatton, “Measurement of 5-HIAA levels in ventricular CSF (by LCEC) and in striatum (by in vivo voltammetry) during pharmacological modification of serotonin metabolism in the rat,” Journal of Neural Transmission, vol. 62, pp. 117–124, 1985.
- M. Stanley, L. Traskman, and K. Dorovine, “Correlations between aminergic metabolites simultaneously obtained from human CSF and brain,” Life Sciences, vol. 37, no. 14, pp. 1279–1286, 1985. View at Publisher · View at Google Scholar
- H. M. van Praag, “Can stress cause depression?” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 28, no. 5, pp. 891–907, 2004. View at Publisher · View at Google Scholar · View at PubMed
- J. M. Abadie, B. Wright, G. Correa, E. S. Browne, J. R. Porter, and F. Svec, “Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat: the obesity research program,” Diabetes, vol. 42, no. 5, pp. 662–669, 1993.
- B. H. C. Westerink, P. Enrico, J. Feimann, and J. B. de Vries, “The pharmacology of mesocortical dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and prefrontal cortex of the rat brain,” Journal of Pharmacology and Experimental Therapeutics, vol. 285, no. 1, pp. 143–154, 1998.
- M. D. Doherty and V. M. Pickel, “Targeting of serotonin 1A receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain,” Journal of Comparative Neurology, vol. 433, no. 3, pp. 390–400, 2001. View at Publisher · View at Google Scholar
- A. A. Gershon, T. Vishne, and L. Grunhaus, “Dopamine D2-like receptors and the antidepressant response,” Biological Psychiatry, vol. 61, no. 2, pp. 145–153, 2007. View at Publisher · View at Google Scholar · View at PubMed
- R. M. Sapolsky, “Why stress is bad for your brain,” Science, vol. 273, no. 5276, pp. 749–750, 1996.
- M. E. Kozisek, D. Middlemas, and D. B. Bylund, “The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment,” Neuropharmacology, vol. 54, no. 2, pp. 251–257, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Lahmame, C. del Arco, A. Pazos, M. Yritia, and A. Armario, “Are Wistar-Kyoto rats a genetic animal model of depression resistant to antidepressants?” European Journal of Pharmacology, vol. 337, no. 2-3, pp. 115–123, 1997. View at Publisher · View at Google Scholar
- I. M. Goodyer, J. Herbert, and A. Tamplin, “Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry,” Psychological Medicine, vol. 33, no. 4, pp. 601–610, 2003. View at Publisher · View at Google Scholar
- L. N. Parker, E. R. Levin, and E. T. Lifrak, “Evidence for adrenocortical adaptation to severe illness,” Journal of Clinical Endocrinology and Metabolism, vol. 60, no. 5, pp. 947–952, 1985.
- J. Herbert, I. M. Goodyear, P. M. E. Altham, J. Pearson, S. M. Secher, and H. M. Shiers, “Adrenal secretion and major depression in 8- to 16-year-olds, II. Influence of co-morbidity at presentation,” Psychological Medicine, vol. 26, no. 2, pp. 257–263, 1996.
- P. L. Delgado and F. A. Moreno, “Role of norepinephrine in depression,” Journal of Clinical Psychiatry, vol. 61, supplement 1, pp. 5–12, 2000.
- P. L. Delgado, “Depression: the case for a monoamine deficiency,” Journal of Clinical Psychiatry, vol. 61, supplement 6, pp. 7–11, 2000.
- S. B. Pinnock, S. E. Lazic, H. T. Wong, I. H. W. Wong, and J. Herbert, “Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat,” Neuroscience, vol. 158, no. 4, pp. 1644–1651, 2009. View at Publisher · View at Google Scholar · View at PubMed