Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study

Table 1

Mean basal levels of monoamines and their metabolites in the four different limbic brain regions (± SEM) of 34-35 day old Wistar and WKY rats (pmol/mg protein).

Brain Region	Strain	DOPA	DA	DOPAC	HVA	5HT	5HIAA
Nac	Wistar	7.03±3.22	70.7±7	55.6±8.2	30.9±1.4	2.95±0.2	11.1±1.28
	WKY	3.31±0.95	69.6±4	53.6±2.6	26±1.5^#	1.9±0.71	5.67±1.05 *
VTA	Wistar	2±1.7	10.9±5.1	16.57±9.17	1.49±0.68	3.48±2.32	4.58±2.96
	WKY	14.15±1.7^**	10.6±6.7	3.12±1.3	5.55±4.8	2.48±1.2	1.16±0.83
Hypothalamus	Wistar	49.7±6.14	197±52.1	57.6±2.9	30.4±8.2	16.56±4.4	114±10.2
	WKY	88.2±17.2^#	96±30.4	107.7±7.7^**	31.8±9.5	17.08±4.6	83.8±5.7 *
Amydgala	Wistar	11.84±1.67	6.88±1.2	2.59±1	4.70±1.1	2.25±0.2	1.38±0.8
	WKY	8.35±1.2	7.91±1.5	4.74±1.2	2.86±1.6	2.02±1.1	4.29±0.9 *

^∗∗𝑃<.01 Wistar versus WKY; ^∗𝑃<.05 Wistar versus WKY; ^#𝑃<.1 Wistar versus WKY.