Advances in Pharmacological Sciences
Volume 2010 (2010), Article ID 534184, 10 pages
doi:10.1155/2010/534184
Research Article
Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition
1CICS—Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal
2Centro Hospitalar da Cova da Beira E.P.E., Quinta do Alvito, 6200-251 Covilhã, Portugal
Received 8 November 2009; Revised 7 January 2010; Accepted 16 January 2010
Academic Editor: Masahiro Oike
Copyright © 2010 E. Álvarez et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- P. Y. Liu, A. K. Death, and D. J. Handelsman, “Androgens and cardiovascular disease,” Endocrine Reviews, vol. 24, no. 3, pp. 313–340, 2003.
- M. R. Adams, J. K. Williams, and J. R. Kaplan, “Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 5, pp. 562–570, 1995.
- R. B. Melchert and A. A. Welder, “Cardiovascular effects of androgenic-anabolic steroids,” Medicine and Science in Sports and Exercise, vol. 27, no. 9, pp. 1252–1262, 1995.
- P. Alexandersen, J. Haarbo, and C. Christiansen, “The relationship of natural androgens to coronary heart disease in males: a review,” Atherosclerosis, vol. 125, no. 1, pp. 1–13, 1996. View at Publisher · View at Google Scholar
- K. M. English, R. D. Jones, T. H. Jones, A. H. Morice, and K. S. Channer, “Aging reduces the responsiveness of coronary arteries from male Wistar rats to the vasodilatory action of testosterone,” Clinical Science, vol. 99, no. 1, pp. 77–82, 2000.
- K. M. English, O. Mandour, R. P. Steeds, M. J. Diver, T. H. Jones, and K. S. Channer, “Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms,” Heart, vol. 21, no. 11, pp. 890–894, 2000.
- K. M. English, R. P. Steeds, T. H. Jones, M. J. Diver, and K. S. Channer, “Low-dose transdermal testosterone therapy improves angina threshold in men with chromic stable angina: a randomized, double-blind, placebo-controlled study,” Circulation, vol. 102, no. 16, pp. 1906–1911, 2000.
- R. D. Jones, P. J. Pugh, T. H. Jones, and K. S. Channer, “The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?” British Journal of Pharmacology, vol. 138, no. 5, pp. 733–744, 2003. View at Publisher · View at Google Scholar · View at PubMed
- O. Yildiz and M. Seyrek, “Vasodilating mechanisms of testosterone,” Experimental and Clinical Endocrinology and Diabetes, vol. 115, no. 1, pp. 1–6, 2007. View at Publisher · View at Google Scholar · View at PubMed
- E. Cairrão, E. Álvarez, A. J. Santos-Silva, and I. Verde, “Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 376, no. 5, pp. 375–383, 2008. View at Publisher · View at Google Scholar · View at PubMed
- P. Tep-areenan, D. A. Kendall, and M. D. Randall, “Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels,” British Journal of Pharmacology, vol. 135, no. 3, pp. 735–740, 2002.
- P. Yue, K. Chatterjee, C. Beale, P. A. Poole-Wilson, and P. Collins, “Testosterone relaxes rabbit coronary arteries and aorta,” Circulation, vol. 91, no. 4, pp. 1154–1160, 1995.
- A. Q. Ding and J. N. Stallone, “Testosterone-induced relaxation of rat aorta is androgen structure specific and involves channel activation,” Journal of Applied Physiology, vol. 91, no. 6, pp. 2742–2750, 2001. View at Scopus
- P. Tep-areenan, D. A. Kendall, and M. D. Randall, “Mechanisms of vasorelaxation to testosterone in the rat aorta,” European Journal of Pharmacology, vol. 465, no. 1-2, pp. 125–132, 2003. View at Publisher · View at Google Scholar
- V. P. Deenadayalu, R. E. White, J. N. Stallone, X. Gao, and A. J. Garcia, “Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel,” American Journal of Physiology, vol. 281, no. 4, pp. H1720–H1727, 2001.
- J. Hall, R. D. Jones, T. H. Jones, K. S. Channer, and C. Peers, “Selective inhibition of L-type channels in A7r5 cells by physiological levels of testosterone,” Endocrinology, vol. 147, no. 6, pp. 2675–2680, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J. L. Scragg, R. D. Jones, K. S. Channer, T. H. Jones, and C. Peers, “Testosterone is a potent inhibitor of L-type channels,” Biochemical and Biophysical Research Communications, vol. 318, no. 2, pp. 503–506, 2004. View at Publisher · View at Google Scholar · View at PubMed
- H. Honda, T. Unemoto, and H. Kogo, “Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats,” Hypertension, vol. 34, no. 6, pp. 1232–1236, 1999.
- E. Won, J. Won, S. Kwon, Y. Lee, T. Nam, and D. Ahn, “Testosterone causes simultaneous decrease of []I and tension in rabbit coronary arteries: by opening voltage dependent potassium channels,” Yonsei Medical Journal, vol. 44, no. 6, pp. 1027–1033, 2003.
- O. Yildiz, M. Seyrek, H. Gul, et al., “Testosterone relaxes human internal mammary artery in vitro,” Journal of Cardiovascular Pharmacology, vol. 45, no. 6, pp. 580–585, 2005. View at Publisher · View at Google Scholar
- J. K. Liao, “Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction,” Circulation Research, vol. 99, no. 3, pp. 238–239, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. S. Moreland, A. H. Lichtenstein, and A. V. Chobanian, “Effects of hypertension on hypercholesterolemia-induced changes in contraction of rabbit aorta and carotid artery,” European Journal of Pharmacology, vol. 307, no. 1, pp. 55–64, 1996. View at Publisher · View at Google Scholar
- A. Bergdahl, M. F. Gomez, K. Dreja, et al., “Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated entry dependent on TRPC1,” Circulation Research, vol. 93, no. 9, pp. 839–847, 2003. View at Publisher · View at Google Scholar · View at PubMed
- D. K. Bowles, C. L. Heaps, J. R. Turk, K. K. Maddali, and E. M. Price, “Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation,” Journal of Applied Physiology, vol. 96, no. 6, pp. 2240–2248, 2004. View at Publisher · View at Google Scholar · View at PubMed
- Y.-J. Ren, X.-H. Xu, C.-B. Zhong, N. Feng, and X.-L. Wang, “Hypercholesterolemia alters vascular functions and gene expression of potassium channels in rat aortic smooth muscle cells,” Acta Pharmacologica Sinica, vol. 22, no. 3, pp. 274–278, 2001.
- U. C. Luft, R. Bychkov, M. Gollasch, et al., “Farnesol blocks the L-type channel by targeting the a1C subunit,” Arteriosclerosis Thrombosis and Vascular Biology, vol. 19, no. 4, pp. 959–966, 1999.
- J.-B. Roullet, U. C. Luft, H. Xue, et al., “Farnesol inhibits L-type channels in vascular smooth muscle cells,” The Journal of Biological Chemistry, vol. 272, no. 51, pp. 32240–32246, 1997. View at Publisher · View at Google Scholar
- J.-B. Roullet, H. Xue, J. Chapman, P. McDougal, C. M. Roullet, and D. A. McCarron, “Farnesyl analogues inhibit vasoconstriction in animal and human arteries,” Journal of Clinical Investigation, vol. 97, no. 10, pp. 2384–2390, 1996.
- C. E. Costarella, J. N. Stallone, G. W. Rutecki, and F. C. Whittier, “Testosterone causes direct relaxation of rat thoracic aorta,” Journal of Pharmacology and Experimental Therapeutics, vol. 277, no. 1, pp. 34–39, 1996.
- M. Perusquía, R. Hernández, M. A. Morales, M. G. Campos, and C. M. Villalón, “Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta,” General Pharmacology, vol. 27, no. 1, pp. 181–185, 1996. View at Publisher · View at Google Scholar
- T. M. Chou, K. Sudhir, S. J. Hutchison, et al., “Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo,” Circulation, vol. 94, no. 10, pp. 2614–2619, 1996.
- C. M. Webb, J. G. McNeill, C. S. Hayward, D. de Zeigler, and P. Collins, “Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease,” Circulation, vol. 100, no. 16, pp. 1690–1696, 1999.
- J. Navarro-Dorado, L. M. Orensanz, P. Recio, et al., “Mechanisms involved in testosterone-induced vasodilatation in pig prostatic small arteries,” Life Sciences, vol. 83, no. 15-16, pp. 569–573, 2008. View at Publisher · View at Google Scholar · View at PubMed
- M. Barbagallo, L. J. Dominguez, G. Licata, et al., “Effect of testosterone on intracellular in vascular smooth muscle cells,” American Journal of Hypertension, vol. 14, no. 12, pp. 1273–1275, 2001.
- M. Perusquía and C. M. Villalón, “Possible role of channels in the vasodilating effect of 5--dihydrotestosterone in rat aorta,” European Journal of Pharmacology, vol. 371, no. 2-3, pp. 169–178, 1999.
- L. M. Montaño, E. Calixto, A. Figueroa, E. Flores-Soto, V. Carbajal, and M. Perusquía, “Relaxation of androgens on rat thoracic aorta: testosterone concentration dependent agonist/antagonist L-type channel activity, and 5-dihydrotestosterone restricted to L-type channel blockade,” Endocrinology, vol. 149, no. 5, pp. 2517–2526, 2008. View at Publisher · View at Google Scholar · View at PubMed
- J. L. Scragg, M. L. Dallas, and C. Peers, “Molecular requirements for L-type channel blockade by testosterone,” Cell Calcium, vol. 42, no. 1, pp. 11–15, 2007. View at Publisher · View at Google Scholar · View at PubMed
- C. A. Heinlein and C. Chang, “The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions,” Molecular Endocrinology, vol. 16, no. 10, pp. 2181–2187, 2002. View at Publisher · View at Google Scholar
- T. Simoncini and A. R. Genazzani, “Non-genomic actions of sex steroid hormones,” European Journal of Endocrinology, vol. 148, no. 3, pp. 281–292, 2003. View at Publisher · View at Google Scholar
- G. Michels and U. C. Hoppe, “Rapid actions of androgens,” Frontiers in Neuroendocrinology, vol. 29, no. 2, pp. 182–198, 2008. View at Publisher · View at Google Scholar · View at PubMed
- R. D. Jones, K. M. English, T. H. Jones, and K. S. Channer, “Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action,” Clinical Science, vol. 107, no. 2, pp. 149–158, 2004. View at Publisher · View at Google Scholar · View at PubMed
- M. Seyrek, O. Yildiz, H. B. Ulusoy, and V. Yildirim, “Testosterone relaxes isolated human radial artery by potassium channel opening action,” Journal of Pharmacological Sciences, vol. 103, no. 3, pp. 309–316, 2007. View at Publisher · View at Google Scholar
- O. Yildiz, M. Seyrek, H. C. Irkilata, I. Yildirim, L. Tahmaz, and M. Dayanc, “Testosterone might cause relaxation of human corpus cavernosum by potassium channel opening action,” Urology, vol. 74, no. 1, pp. 229–232, 2009. View at Publisher · View at Google Scholar · View at PubMed
- J. G. Murphy and R. A. Khalil, “Decreased []i during inhibition of coronary smooth muscle contraction by 17-estradiol, progesterone, and testosterone,” Journal of Pharmacology and Experimental Therapeutics, vol. 291, no. 1, pp. 44–52, 1999.
- R. Iliescu, L. A. Campos, W.-P. Schlegel, I. Morano, O. Baltatu, and M. Bader, “Androgen receptor independent cardiovascular action of the antiandrogen flutamide,” Journal of Molecular Medicine, vol. 81, no. 7, pp. 420–427, 2003. View at Publisher · View at Google Scholar · View at PubMed
- Z. F. Ba, P. Wang, J. F. Kuebler, L. W. Rue III, K. I. Bland, and I. H. Chaudry, “Flutamide induces relaxation in large and small blood vessels,” Archives of Surgery, vol. 137, no. 10, pp. 1180–1186, 2002.
- M. Barbagallo, L. J. Dominguez, G. Licata, et al., “Vascular effects of progesterone: role of cellular calcium regulation,” Hypertension, vol. 37, no. 1, pp. 142–147, 2001.
- J. K. Crews and R. A. Khalil, “Antagonistic effects of 17 b-Estradiol, progesterone, and testosterone on entry mechanisms of coronary vasoconstriction,” Arteriosclerosis Thrombosis and Vascular Biology, vol. 19, no. 4, pp. 1034–1040, 1999.
- D. O. Ruehlmann, J. R. Steinert, M. A. Valverde, R. Jacob, and G. E. Mann, “Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type channels in smooth muscle cells,” FASEB Journal, vol. 12, no. 7, pp. 613–619, 1998.