Chronic Treatment with a Promnesiant GABA-A -Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model
Table 2
Analysis of GO categories among the genes differentially expressed in the hippocampus of Ts65Dn mice after α5IA and behavioral stimulation. In bold GO categories related to neurogenesis processes.
GO term
Description
value
Enrichment analysis of GO biological processes associated with genotype
GO:0051272
Positive regulation of cellular component movement
GO:0007216
Metabotropic glutamate receptor signaling pathway
GO:0032879
Regulation of localization
GO:0016265
Death
GO:0009798
Axis specification
GO:0006414
Translational elongation
GO:0030335
Positive regulation of cell migration
GO:2000147
Positive regulation of cell motility
GO:0008219
Cell death
GO:0065008
Regulation of biological quality
GO:0012501
Programmed cell death
GO:0008624
Induction of apoptosis by extracellular signals
GO:0040017
Positive regulation of locomotion
GO:0008283
Cell proliferation
GO:0000578
Embryonic axis specification
GO:0006916
Antiapoptosis
GO:0007049
Cell cycle
Enrichment analysis of GO biological processes associated with α5IA treatment
GO:0046883
Regulation of hormone secretion
GO:0030335
Positive regulation of cell migration
GO:2000147
Positive regulation of cell motility
GO:0040017
Positive regulation of locomotion
GO:0051272
Positive regulation of cellular component movement
GO:0048869
Cellular developmental process
GO:0007176
Regulation of epidermal growth factor receptor activity
GO:0040008
Regulation of growth
GO:0051270
Regulation of cellular component movement
GO:0000302
Response to reactive oxygen species
GO:0030334
Regulation of cell migration
GO:0048519
Negative regulation of biological process
GO:0009888
Tissue development
GO:0006012
Galactose metabolic process
GO:0009896
Positive regulation of catabolic process
GO:0030154
Cell differentiation
GO:2000145
Regulation of cell motility
GO:0035413
Positive regulation of catenin import into nucleus