Research Article

Chronic Treatment with a Promnesiant GABA-A 𝜶 𝟓 -Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

Table 2

Analysis of GO categories among the genes differentially expressed in the hippocampus of Ts65Dn mice after α5IA and behavioral stimulation. In bold GO categories related to neurogenesis processes.

GO termDescription 𝑃 value

Enrichment analysis of GO biological processes associated with genotype
GO:0051272Positive regulation of cellular component movement 2 . 9 3 𝐸 4
GO:0007216Metabotropic glutamate receptor signaling pathway 𝟐 . 𝟗 𝟔 𝐸 𝟒
GO:0032879Regulation of localization 3 . 3 𝐸 4
GO:0016265Death 𝟑 . 𝟓 𝟓 𝐸 𝟒
GO:0009798Axis specification 3 . 5 8 𝐸 4
GO:0006414Translational elongation 3 . 7 7 𝐸 4
GO:0030335Positive regulation of cell migration 𝟒 . 𝟐 𝟏 𝐸 𝟒
GO:2000147Positive regulation of cell motility 𝟒 . 𝟐 𝟏 𝐸 𝟒
GO:0008219Cell death 𝟒 . 𝟒 𝟗 𝐸 𝟒
GO:0065008Regulation of biological quality 4 . 6 6 𝐸 4
GO:0012501Programmed cell death 𝟓 . 𝟑 𝐸 𝟒
GO:0008624Induction of apoptosis by extracellular signals 𝟓 . 𝟒 𝟒 𝐸 𝟒
GO:0040017Positive regulation of locomotion 7 . 3 2 𝐸 4
GO:0008283Cell proliferation 𝟕 . 𝟕 𝟕 𝐸 𝟒
GO:0000578Embryonic axis specification 7 . 9 6 𝐸 4
GO:0006916Antiapoptosis 𝟖 . 𝟏 𝟒 𝐸 𝟒
GO:0007049Cell cycle 𝟗 . 𝟑 𝐸 𝟒

Enrichment analysis of GO biological processes associated with α5IA treatment
GO:0046883Regulation of hormone secretion 4 . 3 5 𝐸 5
GO:0030335Positive regulation of cell migration 𝟒 . 𝟖 𝟗 𝐸 𝟓
GO:2000147Positive regulation of cell motility 𝟒 . 𝟖 𝟗 𝐸 𝟓
GO:0040017Positive regulation of locomotion 9 . 1 9 𝐸 5
GO:0051272Positive regulation of cellular component movement 1 . 0 4 𝐸 4
GO:0048869Cellular developmental process 𝟏 . 𝟒 𝟗 𝐸 𝟒
GO:0007176Regulation of epidermal growth factor receptor activity 𝟑 . 𝟑 𝟖 𝐸 𝟒
GO:0040008Regulation of growth 𝟓 . 𝟏 𝟔 𝐸 𝟒
GO:0051270Regulation of cellular component movement 5 . 9 𝐸 4
GO:0000302Response to reactive oxygen species 𝟓 . 𝟗 𝟖 𝐸 𝟒
GO:0030334Regulation of cell migration 𝟔 . 𝟖 𝟏 𝐸 𝟒
GO:0048519Negative regulation of biological process 7 . 5 7 𝐸 4
GO:0009888Tissue development 𝟖 . 𝟒 𝟔 𝐸 𝟒
GO:0006012Galactose metabolic process 9 . 1 2 𝐸 4
GO:0009896Positive regulation of catabolic process 9 . 1 5 𝐸 4
GO:0030154Cell differentiation 𝟗 . 𝟐 𝟒 𝐸 𝟒
GO:2000145Regulation of cell motility 𝟗 . 𝟑 𝟑 𝐸 𝟒
GO:0035413Positive regulation of catenin import into nucleus 9 . 6 7 𝐸 4
GO:0031331Positive regulation of cellular catabolic process 9 . 9 8 𝐸 4