About this Journal Submit a Manuscript Table of Contents
Advances in Pharmacological Sciences
Volume 2011 (2011), Article ID 195271, 5 pages
http://dx.doi.org/10.1155/2011/195271
Research Article

Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study

1Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur 440018, India
2Department of Pharmacology, Shree Sathya Sai Medical College and Research Institute, Chennai 603108, India

Received 21 August 2011; Revised 3 November 2011; Accepted 3 November 2011

Academic Editor: Mustafa F. Lokhandwala

Copyright © 2011 Ganesh N. Dakhale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. E. Mesallamy, S. Suwailem, and N. Hamdy, “Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients,” Mediators of Inflammation, vol. 2007, Article ID 73635, 7 pages, 2007. View at Publisher · View at Google Scholar · View at PubMed
  2. D. H. Alamdari, K. Paletas, T. Pegiou, M. Sarigianni, C. Befani, and G. A. Koliakos, “A novel assay for the evaluation of the prooxidant-antioxidant balance, before and after antioxidant vitamin administration in type II diabetes patients,” Clinical Biochemistry, vol. 40, no. 3-4, pp. 248–254, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. Gupta and S. Chari, “Proxidant and antioxidant status in patients of type II diabetes mellitus with IHD,” Indian Journal of Clinical Biochemistry, vol. 21, no. 2, pp. 118–122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Bianchi, R. Miccoli, G. Daniele, G. Penno, and S. Del Prato, “Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? yes,” Diabetes care, vol. 32, no. 2, pp. 342–348, 2009. View at Scopus
  5. G. T. Fadupin, A. U. Akpoghor, and K. A. Okunade, “A comparative study of serum ascorbic acid level in people with and without type 2 diabetes in Ibadan, Nigeria,” African Journal of Medicine and Medical Sciences, vol. 36, no. 4, pp. 335–339, 2007. View at Scopus
  6. M. A. Ardekani and A. S. Ardekani, “Effect of vitamin C on blood glucose, serum lipids & serum insulin in type II diabetes patients,” Indian Journal of Medical Research, vol. 126, no. 5, pp. 471–474, 2007. View at Scopus
  7. L. A. Sargeant, N. J. Wareham, S. Bingham et al., “Vitamin C and hyperglycemia in the European prospective investigation into cancer—Norfolk (EPIC-Norfolk) study: a population based study,” Diabetes Care, vol. 23, no. 6, pp. 726–732, 2000. View at Scopus
  8. N. Bishop, C. J. Schorah, and J. K. Wales, “The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study,” Diabetic Medicine, vol. 2, no. 2, pp. 121–124, 1995. View at Scopus
  9. A. Kyaw, “A simple colorimetric method for ascorbic acid determination in blood plasma,” Clinica Chimica Acta, vol. 86, no. 2, pp. 153–157, 1978. View at Scopus
  10. P. Sridulyakul, D. Chakraphan, and S. Patumraj, “Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats,” Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 315–321, 2006. View at Scopus
  11. M. A. Ardekani, J. Mohiti, E. Amirchaghmaghi, and M. Modarresi, “The effect of vitamin C supplementation on insulin level, HbA1c and blood glucose in type 2 diabetic patients,” Journal of Kerman University of Medical Sciences, vol. 11, pp. 12–18, 2006.
  12. R. D. Bonnefont, J. P. Bastard, M. C. Jaudon, and J. Delattre, “Consequences of the diabetic status on the oxidant/antioxidant balance,” Diabetes and Metabolism, vol. 26, no. 3, pp. 163–176, 2000.
  13. A. Ceriello, N. Bortolotti, A. Crescentini et al., “Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects,” European Journal of Clinical Investigation, vol. 28, no. 4, pp. 329–333, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. I. B. Hirsch, D. H. Atchley, E. Tsai, R. F. Labbé, and A. Chait, “Ascorbic acid clearance in diabetic nephropathy,” Journal of Diabetes and its Complications, vol. 12, no. 5, pp. 259–263, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. T. E. Vincent, S. Mendiratta, and J. M. May, “Inhibition of aldose reductase in human erythrocytes by vitamin C,” Diabetes Research and Clinical Practice, vol. 43, no. 1, pp. 1–8, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Srivatsan, S. Das, R. Gadde et al., “Antioxidants and lipid peroxidation status in diabetic patients with and without complications,” Archives of Iranian Medicine, vol. 12, no. 2, pp. 121–127, 2009. View at Scopus
  17. J. Eriksson and A. Kohvakka, “Magnesium and ascorbic acid supplementation in diabetes mellitus,” Annals of Nutrition and Metabolism, vol. 39, no. 4, pp. 217–223, 1995. View at Scopus
  18. J. Eriksson, A. Kohvakka, V. E. Kagan, M. Melhem, and R. K. Studer, “Effects of supplementation with vitamin C or E on albuminuria, glomerular IGF-β and glomerular size in diabetics,” Journal of the American Society of Nephrology, vol. 89, no. 9, pp. 1405–1414, 1997.
  19. P. Sridulyakul, D. Chakraphan, and S. Patumraj, “Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats,” Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 315–321, 2006. View at Scopus
  20. S. J. Davie, B. J. Gould, and J. S. Yudkin, “Effect of vitamin C on glycosylation of proteins,” Diabetes, vol. 41, no. 2, pp. 167–173, 1992. View at Scopus
  21. E. Szaleczky, J. Prechl, E. Ruzicska et al., “Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients,” Medical Science Monitor, vol. 4, no. 2, pp. 241–244, 1998. View at Scopus
  22. M. Jukka, K. Paul, J. Ritva, and R. Antti, “Dietary antioxidant intake and risk of type 2 diabetes,” Diabetes Care, vol. 27, no. 2, pp. 362–366, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Sébastien, C. Aline, B. Sandrine et al., “Antioxidant supplementation does not affect fasting plasma glucose in the supplementation with antioxidant vitamins and minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations,” American Journal of Clinical Nutrition, vol. 84, no. 2, pp. 395–399, 2006. View at Scopus