Table 1: Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits ( 𝑛 = 1 0 ) .

ControlAANa treatment 𝑃 value

CL (mL/kg/min)20.77 ± 3.739.10 ± 2.45.010
𝑘 1 0 ( m i n 1 )0.091 ± 0.0090.040 ± 0.009<.001
𝑘 1 2 ( m i n 1 )0.053 ± 0.0180.024 ± 0.005.104
𝑘 2 1 ( m i n 1 )0.057 ± 0.0080.039 ± 0.009.147
𝛼 - 𝑡 1 / 2 (min)5.41 ± 1.1010.85 ± 2.22.016
𝛽 - 𝑡 1 / 2 (min)25.09 ± 3.2594.28 ± 28.56.026
Vc (mL/kg)228.72 ± 30.38246.09 ± 36.84.713
𝑉 s s (mL/kg)404.26 ± 51.28509.32 ± 165.07.587
AUC (μg × min/mL)1291.49 ± 192.964376.83 ± 1123.55.017

Data are expressed as the mean ± SE.
CL, clearance; 𝑘 , elimination rate constant; 𝑘 1 0 , elimination rate constant of the central compartment; 𝑘 1 2 , 𝑘 2 1 , the transfer rate constant between the central and peripheral compartments; 𝛼 - 𝑡 1 / 2 , distribution half-life; 𝛽 - 𝑡 1 / 2 , elimination half-life; V, volume of the distribution; Vc, volume of the distribution in the central compartment; 𝑉 s s , volume of the distribution at steady state; AUC, area under the curve.