Table 1: Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits .

Control AANa treatment value CL (mL/kg/min) 20.77 ± 3.73 9.10 ± 2.45 .010 () 0.091 ± 0.009 0.040 ± 0.009 <.001 () 0.053 ± 0.018 0.024 ± 0.005 .104 () 0.057 ± 0.008 0.039 ± 0.009 .147 (min) 5.41 ± 1.10 10.85 ± 2.22 .016 (min) 25.09 ± 3.25 94.28 ± 28.56 .026 Vc (mL/kg) 228.72 ± 30.38 246.09 ± 36.84 .713 (mL/kg) 404.26 ± 51.28 509.32 ± 165.07 .587 AUC (μg × min/mL) 1291.49 ± 192.96 4376.83 ± 1123.55 .017

Data are expressed as the mean ± SE. CL, clearance; , elimination rate constant; , elimination rate constant of the central compartment; , , the transfer rate constant between the central and peripheral compartments; , distribution half-life; , elimination half-life; V, volume of the distribution; Vc, volume of the distribution in the central compartment; , volume of the distribution at steady state; AUC, area under the curve.