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Advances in Pharmacological Sciences
Volume 2011 (2011), Article ID 254619, 7 pages
http://dx.doi.org/10.1155/2011/254619
Review Article

The Pharmacology of Acute Lung Injury in Sepsis

Division of Critical Care, Cincinnati Children's Hospital Medical Center, MLC 2005, Cincinnati, OH 45229-3039, USA

Received 18 February 2011; Accepted 3 May 2011

Academic Editor: William J. Wheeler

Copyright © 2011 Brian Michael Varisco. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute lung injury (ALI) secondary to sepsis is one of the leading causes of death in sepsis. As such, many pharmacologic and nonpharmacologic strategies have been employed to attenuate its course. Very few of these strategies have proven beneficial. In this paper, we discuss the epidemiology and pathophysiology of ALI, commonly employed pharmacologic and nonpharmacologic treatments, and innovative therapeutic modalities that will likely be the focus of future trials.