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Advances in Pharmacological Sciences
Volume 2011 (2011), Article ID 385469, 7 pages
http://dx.doi.org/10.1155/2011/385469
Research Article

Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System

1Novel Drug Delivery and Biomaterial Research Center, National Research Institute for Family Planning, Haidian District Dahuisi Road 12, Beijing 100081, China
2Beijing Institute of Pharmacology and Toxicology, Taiping Road 27. Haidian District, Beijing 100850, China

Received 9 December 2010; Revised 23 January 2011; Accepted 18 February 2011

Academic Editor: Abdelwahab Omri

Copyright © 2011 Meiying Ning et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Preparation and in vitro and in vivo evaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasing API solubility and without resulting in the API degradation. It is found that the VIN release rate was increasing with the citric acid amount at a constant range. Cellulose acetate 398-3 was employed as semipermeable membrane containing polyethylene glycol 6000 and diethyl-o-phthalate as pore-forming agent and plasticizer for controlling membrane permeability. In addition, a clear difference between the pharmacokinetic patterns of VIN immediate release and VIN elementary osmotic pump formulations was revealed. The area under the plasma concentration-time curve after oral administration of elementary osmotic pump formulations was equivalent to VIN immediate release formulation. Furthermore, significant differences found for mean residence time, elimination half-life, and elimination rate constant values corroborated prolonged release of VIN from elementary osmotic pump formulations. These results suggest that the VIN osmotic pump controlled release tablets have marked controlled release characters and the VIN osmotic pump controlled release tablets and the normal tablets were bioequivalent.