Research Article
Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System
Table 1
Composition for core tablets with various molar ratios of vinpocetine and citric acid (unit : mg).
| | Vin : citric acid | 1 : 0 | 1 : 1/3 | 1 : 2/3 | 1 : 1 | 1 : 4/3 | 1 : 6/3 | 1 : 7/3 |
| | Vinpocetine | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | | Citric acid | 0 | 2.74 | 5.48 | 8.22 | 10.96 | 16.44 | 19.2 | | Lactose | 70.17 | 69.25 | 68.34 | 67.43 | 66.51 | 64.69 | 63.77 | | Mannitol | 140.33 | 138.5 | 136.68 | 134.85 | 133.02 | 129.37 | 127.53 | | HPMCK4M | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | | PVPK29–32 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | 15.0 | | M.S. | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 |
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