Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System

Table 4

The pharmacokinetic parameters (vinpocetine) in dogs after oral administration of 15 mg vinpocetine osmotic pump controlled release tablets and immediate release-tablets (average ± SD, 𝑛=6).

Parameters	Immediate release tablets	Osmotic pump controlled release tablets
𝑇max (h)	1.54 ± 0.64	4.83 ± 2.32*
𝐶max (ng/mL)	10.21 ± 1.55	3.62 ± 1.34*
AUC (ng/mL⋅min)	34.80 ± 22.52	40.87 ± 17.75**
𝑇1/2 (h)	3.98 ± 1.06	3.77 ± 1.02**
MRT (h)	13.76 ± 1.5	26.27 ± 2.1*
Ke (h^−1)	0.0756 ± 0.0164	0.0798 ± 0.0159**

* 𝑃<.05, compared to the immediate release tablets (𝑡-test)
** 𝑃>.05, compared to the immediate release tablets (𝑡-test).