Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System : Table 4

Table 4: The pharmacokinetic parameters (vinpocetine) in dogs after oral administration of 15 mg vinpocetine osmotic pump controlled release tablets and immediate release-tablets (average ± SD, ).


Parameters	Immediate release tablets	Osmotic pump controlled release tablets

(h)	1.54 ± 0.64	4.83 ± 2.32*
(ng/mL)	10.21 ± 1.55	3.62 ± 1.34*
AUC (ng/mLmin)	34.80 ± 22.52	40.87 ± 17.75**
(h)	3.98 ± 1.06	3.77 ± 1.02**
MRT (h)	13.76 ± 1.5	26.27 ± 2.1*
Ke (h⁻¹)	0.0756 ± 0.0164	0.0798 ± 0.0159**

* , compared to the immediate release tablets (-test)
** , compared to the immediate release tablets (-test).