Preparation and In Vitro/In Vivo Evaluation of Vinpocetine Elementary Osmotic Pump System : Table 5

Table 5: The pharmacokinetic parameters (vinpocetine metabolite apovincaminic acid) in dogs after oral administration of 15 mg vinpocetine osmotic pump controlled release tablets and immediate release-tablets (average ± SD, ).


Parameters	Immediate release tablets	Osmotic pump controlled release tablets

(h)	1.67 ± 0.31	4.83 ± 1.02*
(ng/mL)	149.28 ± 31.22	52.01 ± 22.39*
AUC (ng/mL·min)	453.20 ± 57.55	377.19 ± 39.89**
T_1/2 (h)	4.63 ± 0.64	4.17 ± 0.22**
MRT (h)	6.8 ± 0.86	17.29 ± 1.02*
Ke (h⁻¹)	0.0851 ± 0.0493	0.1067 ± 0.0981**

* , compared to the immediate release tablets (-test)
** , compared to the immediate release tablets (-test).