The Role of Uridine Adenosine Tetraphosphate in the Vascular System

Table 1

Up₄A and vascular reactivity.

Artery/tissue	Animal	Response	Putative receptor	Signaling	Reference
Thoracic aorta	Rat	Contraction Relaxation	P1, P2X	L-type Ca^2+ channel; Rho kinase; Superoxide; NO; (endothelium-dependent)	[31]
Pulmonary artery	Rat	Contraction	P2Y	Ca^2+ (extracellular and intracellular stores)	[36]
Thoracic aorta	Mouse	Contraction Relaxation			[41]
Perfused kidney	Rat	Contraction Relaxation	P2X1,; P2Y2,; P2Y4; P2Y1,; P2Y2	NO	[14]; [37]; [37]
Perfused afferent arterioles	Mouse	Contraction			[38]

NO: nitric oxide. Details are shown in the text.