Table 1: Up4A and vascular reactivity.

Artery/tissueAnimalResponsePutative receptorSignalingReference

Thoracic aortaRatContraction RelaxationP1, P2XL-type C a 2 + channel
Rho kinase
Superoxide
NO
(endothelium-dependent)
[31]

Pulmonary arteryRatContractionP2Y C a 2 + (extracellular and intracellular stores)[36]

Thoracic aortaMouseContraction Relaxation[41]

Perfused kidneyRatContraction RelaxationP2X1,
P2Y2,
P2Y4
P2Y1,
P2Y2
NO[14]
[37]
[37]

Perfused afferent arteriolesMouseContraction[38]

NO: nitric oxide. Details are shown in the text.