A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

Figure 2

The effects of (a) L-838,417 and (b) TPA023 on complete Freund’s adjuvant-induced thermal hyperalgesia in the rat. Data are means±sem. 𝑛=7-8. Data are expressed as paw withdrawal latency (PWL). BL: baseline. (∗=𝑃<0.05, ∗∗=𝑃<0.01, ANOVA compared to vehicle-treated group).

(a)

(b)