A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

Figure 5

The effects of (a) L-838,417 and (b) TPA023 on spinal nerve ligation-induced static allodynia in the rat. Data are means±sem. 𝑛=10. Data are expressed as paw withdrawal threshold (PWT). BL: baseline. (∗=𝑃<0.05, ∗∗=𝑃<0.01 compared to vehicle-treated group. Mann-Whitney nonparametric test).

(a)

(b)