Table 1: In vitro pharmacological property of the GABAergic compounds.

Compound / -ratio
(nM)Efficacy° (%) (nM)Efficacy°(%) (nM)Efficacy°(%) (nM)Efficacy° (%)

TPA023* [26]0.270#0.31110.19210.4150
TPACMP2* [13]0.22180.40230.21450.23180.78
SL65.1498# [28]1745731158083215480.39
Zolpidem20 [29]75§ [30]400 [29]78§ [30]400 [29]80§5000 [29]9§ [30]0.96

°Relative efficacy is defined as the extent of the potentiation of GABA-A EC20-equivalent current produced by the compound compared to that produced by a nonselective full agonist (chlordiazepoxide/diazepam).
*Mean values of 3 experiments in Xenopus oocytes with human recombinant αβ3γ2 receptors; efficacy relative to chlordiazepoxide.
#Mean values of 3 experiments in hek293 cells with recombinant rat receptors αβ2γ2; efficacy relative to chlordiazepoxide.
§Mean values of 3 experiments in Xenopus oocytes with human recombinant αβ2γ2 receptor; efficacy relative to diazepam.