An Overview of the CNS-Pharmacodynamic Profiles of Nonselective and Selective GABA Agonists

Table 3

Use of pharmacodynamic tests in each study.

Study	CHDR99112	CHDR0102	CHDR0105	CHDR0614	CHDR0407
compound	TPA023	TPACMP2	SL65.1498	Alprazolam	Zolpidem
comparator	Lorazepam	Lorazepam	Lorazepam	NA	NA
SEM	Done	Done	Done	Done	Done
Sway	Done	Done	Done	Done	Done
VAS BL	Done	Done	Done	Done	Done
Smooth	ND	ND	Done	Done	Done
Track	ND	ND	ND	Done	Done

ND: not done; NA: not applicable; SEM: saccadic eye movement; Smooth: smooth pursuit; Sway: body sway; VAS BL: VAS Bond and Lader; Track: adaptive tracking.