Table 3: Use of pharmacodynamic tests in each study.

Study CHDR99112 CHDR0102 CHDR0105 CHDR0614 CHDR0407 compound TPA023 TPACMP2 SL65.1498 Alprazolam Zolpidem comparator Lorazepam Lorazepam Lorazepam NA NA SEM Done Done Done Done Done Sway Done Done Done Done Done VAS BL Done Done Done Done Done Smooth ND ND Done Done Done Track ND ND ND Done Done

ND: not done; NA: not applicable; SEM: saccadic eye movement; Smooth: smooth pursuit; Sway: body sway; VAS BL: VAS Bond and Lader; Track: adaptive tracking.