Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco

Table 1

Sedative action of Lavandula officinalis methanolic extract. p.o. means oral route; i.p. means intraperitoneal route; 𝑛 means number of mice per group; sec means seconds; ME: mean methanolic extract; DZP means diazepam. Data are expressed as mean ± SD; 𝑃<0.001 versus the control group.

Test		Control	Diazepam i.p.	Methanolic extract of Lavandula officinalis in mg/kg p.o.
			DZP (3 mg/kg)	ME (100 mg/kg)	ME (200 mg/kg)	ME (400 mg/kg)	ME (600 mg/kg)
Traction test	Re-establishment time	0.09 sec ± 0.0	10 sec ± 0.3	0.08 sec ± 0.5	5 sec ± 0.5*	18 sec ± 0.5*
		𝑛=5	𝑛=5	𝑛=5	𝑛=5	𝑛=5
Fireplace test	Time to go back the tube in seconds	7 sec ± 0.5	>2 min	sec ± 0.5	30 sec ± 1*	0.58 sec ± 1*
		𝑛=5	𝑛=5	𝑛=5	𝑛=5	𝑛=5
Hole-board test	Explored holes during 5 minutes	10±1	0.0±0.0	8±0.1	2 ± 0.0*	1 ± 0.0*
		𝑛=5	𝑛=5	𝑛=5	𝑛=5	𝑛=5