Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco

Table 3

Effect of the methanolic extract of Lavandula officinalis on the onset and duration of sleep in thiopental-treated mice. Mice received thiopental (60 mg/kg, i.p.) 30 min after the pretreatment of methanolic extract (800 and 1000 mg/kg, p.o.) and diazepam (3 mg/kg, i.p.). i.p. means intraperitoneal route; p.o. means oral route; (𝑛=5) means number of mice per group; ME means methanolic extract; D ZP means diazepam. Data are expressed as mean ± SD; 𝑃<0.001 versus the control group.

Group	Dose (mg/kg)	Sleep latency (min)	Sleeping time (min)
Normal	60	8±1	36±3
DZP	3	6±1^∗	75±3^∗
ME	800	12±0.5^∗	45±2^∗
ME	1000	6±1^∗	112±3^∗