Table 5: Gene expression of NHDF after incubation with 10 μg/mL St. John’s Wort polysaccharide fractions in minimal MEM for 6 h, 12 h, and 24 h. Results of RT-PCR with TaqMan assays were normalized to endogenous control 18 srRNA and to the respected expression of target genes in untreated control cells. Regulation was defined as significant with >2 (+) and <0.5 (−). No change in gene expression is shown as “o”.

Polysaccharide fractionEGFRSTAT6FGF7Incubation time

Hp16 h
Hp2ooo
Hp3ooo
Hp4ooo

Hp1ooo12 h
Hp2+oo
Hp3oo+
Hp4oo+

Hp1o24 h
Hp2+o
Hp3oo
Hp4ooo