Figure 3: Effects of 5-HT7 receptor agonists AS-19 (a), E-57431 (b), and E-55888 (c) on body temperature in wild-type and 5-HT7 receptor knockout mice. Subcutaneous administration of AS-19 and E-57431 at 20 mg/kg significantly reduced body temperature in both wild-type and 5-HT7 receptor knockout mice and showed significant differences between both genotypes. However, E-55888 at 20 mg/kg did not reduce the body temperature neither in wild-type nor in 5-HT7 knockout mice. Each bar represents the mean ± S.E.M. (–12). *** versus vehicle corresponding group; #; ### versus corresponding dose in 5-HT7 receptor knockout mice (Bonferroni multiple comparison test post-ANOVA).