|Table 1: Binding profiles of the 5-HT7 receptor agonists AS-19, E-57431, and E-55888.|
|n.s.: not significant (Ki > 1 μM or less than 50% inhibition of specific radioligand binding at 1 μM); |
—: data not available.
gp: guinea pig; h: human; r: rat.
Data obtained from Brenchat et al. [13, 14]
Data in parentheses after Ki values represent the affinity ratio versus 5-HT7 receptors calculated as Ki for the tested receptor/Ki for 5-HT7 receptor. It is expressed as number-fold higher (x) for 5-HT7 than for the tested receptor.
aSee the panel of other receptors assayed .
bSee the panel of other receptors assayed .