Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze
Table 2
Effect of palmatine and other drugs employed on escape latency (EL) of mice using Morris water maze.
Treatments
Dose (kg)−1
EL (sec) Day-6
EL (sec) Day-7
EL (sec) Day-8
EL (sec) Day-9
Control (vehicle) for 10 days
10 mL
105.90 ± 3.28
96.34 ± 3.44
78.38 ± 3.70
54.19 ± 3.44
Physostigmine for 10 days
0.1 mg
104.31 ± 3.06
101.25 ± 2.51
74.09 ± 2.45
33.5 ±2.66c
Scopolamine
0.4 mg
106.62 ± 18.16
87.66 ± 3.75
69.63 ± 3.49
44.44 ± 2.81b
Diazepam
1 mg
105.96 ± 2.59
91.66 ± 2.48
69.47 ± 3.21
42.56 ± 2.52a
Palmatine for 10 days
0.1 mg
103.93 ± 2.95
100.93 ± 3.13
78.09 ± 4.01b
44.22 ± 2.98
Palmatine for 10 days
0.5 mg
100 ± 3.25
88.38 ± 3.84
61.56 ± 2.98c
32.09 ± 2.4b
Palmatine for 10 days
1 mg
99.75 ± 2.80
75.43 ± 3.54b
49.78 ± 2.31
26.06 ± 1.54c
Palmatine for 10 days + scopolamine on 10th day
1 mg + 0.4 mg
107.29 ± 3.01
83.69 ± 3.48
54.75 ± 2.26
28.13 ± 1.33d
Palmatine for 10 days + diazepam on 10th day
1 mg + 1 mg
109.90 ± 2.23
85.21 ± 2.84
55.81 ± 3.39
29.91 ± 1.59e
. Values are expressed as Mean ± SEM. Data was analyzed by one-way ANOVA followed by Tukey’s post-hoc test. (8, 279) = 1.264; (day 6); (8, 279) = 7.147; (day 7); (8, 279) = 11.079; (day 8); (8, 279) = 14.251; (day 9);
a
as compared to control;
b as compared to control;
c as compared to control;
d as compared to scopolamine treated group;
e as compared to diazepam treated group.