Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice

Table 3

Effect of MREt of R. serpentina on fasting blood glucose level in mice.

Groups	Treatments	Initial day (𝐺0)	Final day (𝐺𝑥)	Glycemic change (%)
Group I	Distilled water (1 mL/ kg)	102.25±2.72	98±5.84	−4.16
Group II	Alloxan treated (150 mg/kg)	198.25±4.91	245.50±20.66	23.83
Group III	0.05% DMSO (1 mL/kg)	199.50±5.62	257.25±22.68	28.95
Group IV	Glibenclamide (5 mg/kg)	195.25±3.12	116.50±14.46 ****	−40.46
Group V	MREt (10 mg/kg)	198.25±5.01	96.25±4.94 ****	−51.45
Group VI	MREt (30 mg/kg)	197.50±6.2	105±12.39 ****	−46.84
Group VII	MREt (60 mg/kg)	195.2±5.66	98±6.54 ****	−49.80

Values are expressed as mean ± SEM (𝑛=6). ****𝑃<0.0001, when compared with group II and III at respective day.
Negative (−)/positive (+) signs represent decrease/increase in percent glycemic change at 14th day.