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Advances in Pharmacological Sciences
Volume 2012 (2012), Article ID 465634, 7 pages
http://dx.doi.org/10.1155/2012/465634
Research Article

Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis: Emerging Role of Gamma-Glutamyltransferase

1Faculty of Health Sciences, Anti-Tuberculosis Centre, National Laboratory of Public Health, Marien Ngouabi University, Brazzaville, Democratic Republic of Congo
2Faculty of Health Sciences, Walter Sisulu University, Private Bag X1, Eastern Cape, Mthatha 5117, South Africa

Received 14 December 2011; Accepted 4 February 2012

Academic Editor: Abdelwahab Omri

Copyright © 2012 Etienne Mokondjimobe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 3 4 . 7 ± 5 . 8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% ( 𝑛 = 1 ) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0–day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.