About this Journal Submit a Manuscript Table of Contents
Advances in Pharmacological Sciences
Volume 2012 (2012), Article ID 507278, 6 pages
http://dx.doi.org/10.1155/2012/507278
Research Article

Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats

1Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran
2Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet (KI), Box 210, 17177 Stockholm, Sweden
3Department of Pharmacology and Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil 56135665, Iran
4Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences, Tabriz 5165691749, Iran
5Drug Applied Research Center (DARC), Tabriz University of Medical Sciences, Tabriz 5165665811, Iran
6Department of Cardiac Surgery and Cardiovascular Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5166615573, Iran
7Department of Statistics and Epidemiology, School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran
8Department of Biochemistry and Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5166615731, Iran
9Department of Toxicology, Pharmaceutical Sciences Research Center (PSRC) and School of Pharmacy, Tehran University of Medical Sciences, Tehran 141556451, Iran

Received 20 July 2012; Revised 23 September 2012; Accepted 23 September 2012

Academic Editor: Mustafa F. Lokhandwala

Copyright © 2012 Sadollah Mohammadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Simonneau, I. M. Robbins, M. Beghetti et al., “Updated clinical classification of pulmonary hypertension,” Journal of the American College of Cardiology, vol. 54, no. 1, pp. S43–S54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. R. L. Benza, D. P. Miller, M. Gomberg-Maitland et al., “Predicting survival in pulmonary arterial hypertension: insights from the registry to evaluate early and long-term pulmonary arterial hypertension disease management (REVEAL),” Circulation, vol. 122, no. 2, pp. 164–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. C. E. Huggins, A. A. Domenighetti, T. Pedrazzini, S. Pepe, and L. M. D. Delbridge, “Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice,” Journal of the Renin-Angiotensin-Aldosterone System, vol. 4, no. 3, pp. 186–190, 2003. View at Scopus
  4. E. M. Redout, A. Van Der Toorn, M. J. Zuidwijk et al., “Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure,” American Journal of Physiology, vol. 298, no. 3, pp. H1038–H1047, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Amirshahrokhi, S. Bohlooli, and M. M. Chinifroush, “The effect of methylsulfonylmethane on the experimental colitis in the rat,” Toxicology and Applied Pharmacology, vol. 253, no. 3, pp. 197–202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Ebisuzaki, “Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention,” Anticancer Research, vol. 23, no. 1, pp. 453–458, 2003. View at Scopus
  7. S. Parcell, “Sulfur in human nutrition and applications in medicine,” Alternative Medicine Review, vol. 7, no. 1, pp. 22–44, 2002. View at Scopus
  8. E. M. Debbi, G. Agar, G. Fichman et al., “Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study,” BMC Complementary and Alternative Medicine, vol. 11, article 50, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. E. J. Lim, D. Y. Hong, J. H. Park et al., “Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways,” PLoS ONE, vol. 7, no. 4, Article ID e33361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Garjani, A. Afrooziyan, H. Nazemiyeh, M. Najafi, A. Kharazmkia, and N. Maleki-Dizaji, “Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats,” BMC Complementary and Alternative Medicine, vol. 9, article 28, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. L. Chang, H. S. Sohn, K. C. Chan, C. D. Berdanier, and J. L. Hargrove, “Low dietary protein impairs blood coagulation in BHE/cdb rats,” Journal of Nutrition, vol. 127, no. 7, pp. 1279–1283, 1997. View at Scopus
  12. F. Squadrito, D. Altavilla, G. Squadrito et al., “Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats,” Cardiovascular Research, vol. 45, no. 2, pp. 454–462, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. U. R. Kodavanti, D. L. Costa, and P. A. Bromberg, “Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility,” Environmental Health Perspectives, vol. 106, supplement 1, pp. 111–130, 1998. View at Scopus
  14. “Methylsulfonylmethane (MSM). Monograph,” Alternative Medicine Review, vol. 8, pp. 438–441, 2003.
  15. M. Uchiyama and M. Mihara, “Determination of malonaldehyde precursor in tissues by thiobarbituric acid test,” Analytical Biochemistry, vol. 86, no. 1, pp. 271–278, 1978. View at Scopus
  16. C. Carlino, J. D. Tobias, R. I. Schneider et al., “Pulmonary hemodynamic response to acute combination and monotherapy with sildenafil and brain natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension,” American Journal of the Medical Sciences, vol. 339, no. 1, pp. 55–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Akhavein, E. Jean St-Michel, E. Seifert, and C. V. Rohlicek, “Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats,” Journal of Applied Physiology, vol. 103, no. 1, pp. 287–295, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Dorfmüller, M.-C. Chaumais, M. Giannakouli et al., “Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension,” Respiratory Research, vol. 12, article 119, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Joppa, D. Petrasova, B. Stancak, Z. Dorkova, and R. Tkacova, “Oxidative stress in patients with COPD and pulmonary hypertension,” Wien Klin Wochenschr, vol. 119, pp. 428–434, 2007.
  20. F. Farahmand, M. F. Hill, and P. K. Singal, “Antioxidant and oxidative stress changes in experimental cor pulmonale,” Molecular and Cellular Biochemistry, vol. 260, no. 1, pp. 21–29, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. H. F. Jin, S. X. Du, X. Zhao et al., “Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats,” Acta Pharmacologica Sinica, vol. 29, no. 10, pp. 1157–1166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. H. Kim, D. H. Kim, H. Lim, D. Y. Baek, H. K. Shin, and J. K. Kim, “The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages,” Biological and Pharmaceutical Bulletin, vol. 32, no. 4, pp. 651–656, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. L. Cracowski, C. Cracowski, G. Bessard et al., “Increased lipid peroxidation in patients with pulmonary hypertension,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 6, pp. 1038–1042, 2001. View at Scopus
  24. Z. C. Li, F. Q. Zhang, J. C. Song, Q. B. Mei, and D. H. Zhao, “Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat,” Journal of Applied Physiology, vol. 92, no. 3, pp. 997–1003, 2002. View at Scopus