Table 1: Morphometric parameters and hemodynamic data of control and monocrotaline-injected male rats.

ControlMCT-induced pulmonary hypertension groups. MSM (mg/kg/day)
0100200400

Morphometric parameters
 Body wt (g)265 ± 8204 ± 12*230 ± 10244 ± 21262 ± 110.39<0.01
 Heart (g)0.71 ± 0.130.81 ± 0.190.78 ± 0.180.75 ± 0.200.74 ± 0.170.090.21
 Heart/body wt (mg/g)2.67 ± 0.113.4 ± 0.14**3.44 ± 0.273.23 ± 0.532.84 ± 0.0540.36<0.01
 RV wt (g)0.16 ± 0.010.31 ± 0.04**0.25 ± 0.020.22 ± 0.030.18 ± 0.010.38<0.01
 RV/body wt (mg/g)0.59 ± 0.041.54 ± 0.15**1.09 ± 0.15*0.92 ± 0.270.70 ± 0.380.46<0.01
 LV + S wt (g)0.55 ± 0.020.50 ± 0.010.53 ± 0.020.53 ± 0.010.56 ± 0.020.230.04
 LV + S/body wt (mg/mg)2.08 ± 0.082.46 ± 0.082.33 ± 0.152.24 ± 0.262.15 ± 0.070.150.11
 RV/LV + S0.28 ± 0.020.62 ± 0.07**0.47 ± 0.04*0.42 ± 0.060.33 ± 0.030.50<0.01
 Lung wet (g)1.11 ± 0.063.09 ± 0.14**2.23 ± 0.36*1.99 ± 0.261.28 ± 0.090.60<0.01
 Lung dry (g)0.25 ± 0.010.52 ± 0.02**0.46 ± 0.06*0.41 ± 0.060.27 ± 0.020.50<0.01
 Lung dry/wet0.22 ± 0.030.17 ± 0.02**0.20 ± 0.090.21 ± 0.030.21 ± 0.030.360.01
 Lung wet/body wt (mg/g)4.19 ± 0.1815.17 ± 1.15**9.35 ± 2.06*8.17 ± 2.384.83 ± 0.200.60<0.01
Hemodynamic data
 HR (beats/min)397 ± 31274 ± 19*312 ± 16326 ± 24406 ± 310.47<0.01
 MAP (mmHg)83.28 ± 7.4254.07 ± 7.13**53.100 ± 2.76**58.68 ± 3.149*77.83 ± 1.310.62<0.01
 RVSP (mmHg)22.56 ± 1.6535.87 ± 1.76**29.21 ± 2.7927.65 ± 2.6022.62 ± 2.110.53<0.01
 RV (mmHg/s)1958 ± 402376 ± 116*2196 ± 252130 ± 502027 ± 390.39<0.01
(ms)14.43 ± 0.9222.62 ± 0.83**19.05 ± 1.43*17.44 ± 0.9115.65 ± 0.970.53<0.01

Data are mean ± SE. Significant Tukey's post hoc differences compared with controls are indicated by asterisks (** and * ) and is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; RV: right ventricle; LV: left ventricle; S: septum; wt: weight; HR: heart rate; MAP: mean arterial pressure; RVSP: right ventricular systolic pressure; RV : peak rate of right ventricular pressure; : relaxation time constant.