Table 2: Effects of different doses of methylsulfonylmethane (MSM) on the activities of antioxidant enzymes in rats with monocrotaline-(MCT-) induced pulmonary hypertension.

ControlMCT-induced pulmonary hypertension groups, MSM (mg/kg/day)
0100200400

CAT (U/mL)6.10 ± 0.832.02 ± 0.33*4.16 ± 0.575.02 ± 0.757.98 ± 1.680.48<0.001
SOD (U/mL)203.33 ± 3.80168.33 ± 6.67**206.67 ± 5.11210.00 ± 7.30220.83 ± 3.960.50<0.001
GSH-px (U/mL)10.01 ± 0.127.05 ± 0.62**8.14 ± 1.099.80 ± 0.2510.20 ± 0.200.400.001

Significant Tukey's post hoc differences compared with controls are indicated by asterisks (** and * ) and is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.