Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats

Table 2

Effects of different doses of methylsulfonylmethane (MSM) on the activities of antioxidant enzymes in rats with monocrotaline-(MCT-) induced pulmonary hypertension.

	Control	MCT-induced pulmonary hypertension groups, MSM (mg/kg/day)
		0	100	200	400	𝑟^2	𝑃
CAT (U/mL)	6.10 ± 0.83	2.02 ± 0.33*	4.16 ± 0.57	5.02 ± 0.75	7.98 ± 1.68	0.48	<0.001
SOD (U/mL)	203.33 ± 3.80	168.33 ± 6.67**	206.67 ± 5.11	210.00 ± 7.30	220.83 ± 3.96	0.50	<0.001
GSH-px (U/mL)	10.01 ± 0.12	7.05 ± 0.62**	8.14 ± 1.09	9.80 ± 0.25	10.20 ± 0.20	0.40	0.001

Significant Tukey's post hoc differences compared with controls are indicated by asterisks (**𝑃<0.01 and *𝑃<0.05) and 𝑟² is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.