Table 3: Effects of different doses of methylsulfonylmethane (MSM) on the levels of reduced glutathione (GSH) and disulfide-oxidized glutathione (GSSG) and MDA in rats with monocrotaline- (MCT-) induced pulmonary hypertension.

ControlMCT-induced pulmonary hypertension groups, MSM (mg/kg/day)
0100200400

GSH (nmol/mL)543.54 ± 16.22347.33 ± 41.54*551.65 ± 93.28695.95 ± 106.36774.62 ± 45.620.41<0.01
GSSG (nmol/mL)50.71 ± 2.17 62.98 ± 9.3659.05 ± 4.8051.31 ± 2.410.260.01

Significant Tukey’s post hoc differences compared with controls are indicated by asterisks (** and * ) and is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.