Antinociceptive, Anti-Inflammatory, and Antipyretic Activity of Mangrove Plants: A Mini Review

Table 2

Antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plant species.

No	Plant name	Family	Plant part tested	Observed activity	Test method	Refs
1	Acanthus hirsutus Boiss.	Acanthaceae	Aqueous extract	Antinociceptive	Acetic-acid-induced in mice	[4]
2	Acanthus ilicifolius Linn.		MeOH fraction of leaf extract	Anti-inflammatory	Carrageenan-induced rat paw oedema, COX (1 and 2) and 5-LOX activity	[5]
3	Aegiceras corniculatum (Linn.) Blanco.	Myrsinaceae	n-Hexane, EtOAc and MeOH extracts of stem	Antinociceptive, Anti-inflammatory	Acetic-acid-induced, formalin-induced paw licking and hot plate test in mice	[6]
4	Aegiceras corniculatum (Linn.) Blanco.		MeOH extract of stem	Anti-inflammatory	Rat paw oedema and peritonitis models were employed for in vivo studies. For in vitro studies, human platelets and rat neutrophils were stimulated with Ca(2+)-ionophore A23187 leading to the production of various proinflammatory metabolites, that is, 12-HTT, 12-HETE and LTB(4), and 5-HETE	[7]
5	Avicennia officinalis Linn.	Avicenniaceae	MeOH extract of leaves	Anti-inflammatory	Freunds adjuvant-induced arthritis, carrageenan-, and formalin-induced rat paw oedema	[8]
6	Barringtonia racemosa Linn.	Lecythidaceae	98% n-Hexane, 98% CHCl3 and 95% EtOH extracts of leaf	Anti-inflammatory	Inhibition of nitric oxide formation in RAW 264.7 cells by Griess assay Amount of lipid peroxidation by ferric thiocyanate method	[9]
7	Barringtonia racemosa Linn.		Aqueous bark extract	Antinociceptive	Tail flick, hot plate, and formalin tests in rat	[10]
8	Caesalpinia mimosoides Lamk.	Leguminosae	CH2Cl2 and acetone extracts, pure compounds	Anti-inflammatory	Inhibition of lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW 264.7 cell lines	[11]
9	Ceriops decandra (Griff.) W. Theob.	Rhizophoraceae	EtOH extract of leaf and pneumatophore	Antinociceptive	Acetic-acid-induced in mice	[12]
10	Calophyllum inophyllum Linn.	Clusiaceae	EtOH extract of nut kernel	Anti-inflammatory	Carrageenan- and formalin-induced rat paw oedemas, cotton pellet implantation	[13]
11	Calophyllum inophyllum Linn.		(Pure compounds tested)	Anti-inflammatory	Carrageenan-induced hind paw oedema, cotton pellet granuloma and granuloma pouch techniques, in normal and adrenalectomized rats	[14]
12	Excoecaria agallocha Linn.	Euphorbiaceae	(Pure compounds tested)	Anti-inflammatory	Suppression of the expression of NF-κB and AP-1 targeted genes including TNF-alpha- and IL-6-induced by lipopolysaccharide (LPS) in mouse macrophages Raw 264.7 cells	[15]
13	Nypa fruticans Wurmb.	Arecaceae	MeOH extract of leaf and stem	Antinociceptive	Acetic-acid-induced in mice	[16]
14	Pandanus foetidus Roxb.	Pandanaceae	MeOH extract of leaf	Antinociceptive	Acetic-acid-induced in mice	[17]
15	Pongamia pinnata (L.) Pierre	Fabaceae	70% EtOH extract of leaf	Antinociceptive and antipyretic activity	Hotplate and tail flick, acetic acid writhing and Randall-Selitto nociceptive tests in mice and brewer’s yeast-induced pyrexia in rats	[18]
16	Pongamia pinnata (L.) Pierre		70% EtOH extract of leaf	Anti-inflammatory	Carrageenin, histamine, 5-hydroxytryptamine and prostaglandin E-2-induced hind paw edema, kaolin-carrageenan and formaldehyde-induced hind paw oedema, cotton pellet granuloma models of inflammation	[19]
17	Pongamia pinnata (L.) Pierre		70% EtOH extract of seed	Antinociceptive, Anti-inflammatory	Carrageenan-induced hind paw oedema and Randall-Selitto nociceptive test in rat	[20]
18	Pongamia pinnata (L.) Pierre		PE, CHCl3, acetone and EtOH extracts of seed	Antinociceptive, Anti-inflammatory		[21]
19	Pongamia pinnata (L.) Pierre		70% EtOH extract of seed	Anti-inflammatory	Bradykinin and PGE-1-induced inflammation, histamine and 5-HT-induced inflammation	[22]
20	Tamarix indica Willd.	Tamaricaceae	80% MeOH extract of root	Antinociceptive, Anti-inflammatory	Acetic-acid-induced in mice, using carrageenan induced rat paw oedema	[23]
21	Derris scandens (Roxb.) Benth.	Fabaceae	CHCl3 extracts of leaf and root and pure compounds	Anti-inflammatory	Carrageenan-induced paw oedema in rats	[24]
22	Derris scandens (Roxb.) Benth.		Aqueous extract of stem and pure compounds	Anti-inflammatory	Eicosanoid inhibition	[25]
23	Ipomoea imperati (Vahl) Griseb.		EtOH extract of whole plant	Antinociceptive	Acetic-acid-induced and hot plate test in mice	[26]
24	Ipomoea imperati (Vahl) Griseb.		MeOH-water extract of leaf	Anti-inflammatory	Mouse ear oedema induced by croton oil, arachidonic acid, cotton pellet-induced granulomas, inhibition of Phospholipase A(2) purified from Apis mellifera bee venom	[27]
25	Ipomoea pes-caprae (L.) R-Br.	Convolvulaceae	MeOH extract and two fractions of aerial part	Antinociceptive	Acetic-acid-induced and formalin test in mice	[28]
26	Ipomoea pes-caprae (L.) R-Br.		Pure compounds	Antinociceptive	Acetic-acid-induced and formalin test in mice	[29]
27	Ipomoea pes-caprae (L.) R-Br.		Crude extract and pure compounds	Anti-inflammatory	Inhibition of prostaglandin synthesis in vitro	[30]
28	Ipomoea pes-caprae (L.) R-Br.		Crude extract	Anti-inflammatory	Carrageenan-induced paw oedema and ear oedema induced in rats by arachidonic acid or ethyl phenylpropiolate, inhibition of prostaglandin synthesis in vitro	[31]
29	Heritiera littoralis Aiton	Sterculiaceae	Pure compounds	Anti-inflammatory	Nitric oxide (NO) inhibitory effects using RAW 264.7 macrophage cells	[32]