Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair

Figure 10

Dose-response of the effects of porcine pancreatic elastase (PPE, 0.2 U/g and 0.3 U/g) on respiratory function in mice and its reversal using the anti-beta1 integrin antibody JB1a. The effect of PPE on mean respiratory pressure-volume curves in mice from 35 days (35 d) after instillation and its reversal by JB1a (vehicle = Veh).