Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair

Figure 11

The effects of porcine pancreatic elastase (PPE, 0.3 U/g) on respiratory function in mice and its reversal using the anti-beta1 integrin antibody JB1a (3 mg/kg) in comparison to the anti-beta1 integrin clone B44 (3 mg/kg). (a) The effect of PPE on mean respiratory pressure-volume curves in mice from 35 days (35 d) after instillation and its reversal by JB1a and not B44. (b) Reversal of PPE-induced increase in the quasi-static elastance between 5 and 9 cm H₂O by JB1a treatment (𝐧=𝟔−𝟏𝟎). Asterisks denote statistical significance with *𝐏<𝟎.𝟎𝟓, **𝐏<𝟎.𝟎𝟎𝟓, and ***𝐏<𝟎.𝟎𝟎𝟎𝟓 in comparison to vehicle.

(a)

(b)