Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair
Figure 2
The effects of PPE-induced injury and targeting beta1 integrin using AIIB2 and K20 clones on (a) activation of signalling downstream of beta1 integrin during mechanical stretch (asterisks denotes statistical significance with in comparison to PPE) and (b) beta1 integrin conformational activation indicated by increase in staining using the anti-β1 integrin antibody 9EG7 recognising the ligand competent receptor in comparison to staining using nonconformation dependent antibody (K20).
