Antinociceptive and Anti-Inflammatory Activities of Leaf Methanol Extract of Cotyledon orbiculata L. (Crassulaceae)

Table 1

Effect of leaf methanol extract of Cotyledon orbiculata on acetic acid-induced writhing in mice.

Treatment groups	Dose; (mg/kg)	Number of writhes		Percentage reduction (%)
		Mean±SEM
PS	0.25 mL	28.13	3.92
C. orbiculata	100	13.83*	3.17	51
	200	9.20**	3.04	67
	400	6.75***	1.97	76
Paracetamol	300	2.10***	0.24	93
DMSO	0.25 mL	29.04	2.73	0

^∗𝑃<0.025, ^∗∗𝑃<0.005, ***𝑃<0.001 versus 3% acetic acid (0.20 mL, i.p.) control, ANOVA (𝑛=8). Writhes are expressed as number of counts per 20 minutes.
PS: physiological saline.
DMSO: dimethylsulfoxide.