Table 1: Effect of leaf methanol extract of Cotyledon orbiculata on acetic acid-induced writhing in mice.

Treatment groupsDose
(mg/kg)
Number of writhesPercentage reduction (%)

PS0.25 mL28.133.92

C. orbiculata10013.83*3.1751
2009.20**3.0467
4006.75***1.9776

Paracetamol3002.10***0.2493

DMSO0.25 mL29.042.730

, , *** versus 3% acetic acid (0.20 mL, i.p.) control, ANOVA ( ). Writhes are expressed as number of counts per 20 minutes.
PS: physiological saline.
DMSO: dimethylsulfoxide.