Table 2: Effect of leaf methanol extract of Cotyledon orbiculata on hot-plate-induced nociception in mice.

Treatment groupsDose (mg/kg)Response time (s)
0 min15 min30 min45 min60 min

PS0.25 mL

C. orbiculata100
200
400

Morphine10

DMSO0.25 mL

* , ** , + , ++ versus physiological saline control, ANOVA ( ). The response time in seconds was expressed as .
PS: physiological saline.
DMSO: dimethylsulfoxide.