Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract of Alafia multiflora Stem Barks in Rodents

Table 1

Effects of the aqueous extract of A. multiflora stem bark and diazepam in the open field test in mice.

Groups	Dose (mg/kg)	Number of line traversed	Rearing time (s)	Grooming time (s)	Time spent at the center (s)
Control	—	35 ± 5.2	23.54 ± 5.14	87.54 ± 12.62	5.70 ± 1.36
AM	150	49.12 ± 2.24	29.25 ± 3.46	57.32 ± 13.17	41.22 ± 5.61*
AM	300	48.21 ± 3.56	35.42 ± 2.20*	34.20 ± 6.16**	56.50 ± 4.04*
Diazepam	1	5.40 ± 4.32***	9.10 ± 3.10***	10.70 ± 8.56***	123.00 ± 18.120**

Mice activity was measured 30 min after the last chronic administration of the aqueous extract of A. multiflora or 30 min after the single dose of diazepam administration. Data are expressed as mean ± SEM of 6 animals. *P < 0.05, **P < 0.01, and **P < 0.001, compared to the vehicle-treated control group.