Research Article

Anxiolytic and Antidepressant-Like Effects of the Aqueous Extract of Alafia multiflora Stem Barks in Rodents

Table 2

Effects of repeated administration of the aqueous extract of A. multiflora (i.p.) on the light-dark transition test with mice.

GroupsDose (mg/kg)Latency time (s)Transition numberTime spent in light compartment (s)

Control116.2 ± 12.163.4 ± 0.7338.60 ± 2.26
AM150196.60 ± 8.90***7.2 ± 0.86**53.80 ± 3.13*
AM300181.20 ± 11.20***8.8 ± 0.86***83.60 ± 4.06***
Diazepam157.40 ± 3.73***15.40 ± 1.20***105.00 ± 3.33***

Aqueous extract of A. multiflora stem bark was given (i.p) once per day for 7 days. Diazepam was given (i.p.) only once 30 min prior to the test. Data are expressed as means ± SEM. n = 6 animals per group. *P < 0.05; **P < 0.01; ***P < 0.001 versus control.