Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats
Figure 3
Effect of coenzyme Q10 (CoQ10) on caspase 3 immunohistochemical staining of doxorubicin- (Dox-) treated and untreated rat kidney. Localization of caspase 3 immunoreactivity in the kidney cortex (×1000) of ((a) and (b)) untreated control and low dose CoQ10 treated (CoQ10L) groups, respectively, showing negative immunoreactivity; (c) high dose CoQ10 treated group (CoQ10H) showing faint expression within the glomeruli (G) and the renal tubules (arrow); (d) Dox-treated group showing high expression in the renal glomeruli (G) and renal tubules. The expression is mainly cytoplasmic, but with some nuclei showing positive expression (arrows); (e) Dox/CoQ10L group showing faint expression within the glomeruli (G) and the renal tubules (arrow); (f) Dox/CoQ10H group showing high expression in the glomeruli (G) and the renal tubules (arrow).
