Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats

Table 2

Effect of coenzyme Q10 (CoQ10) on severity of histopathological lesions in doxorubicin- (Dox-) induced nephrotoxicity in rats.

Groups	Tubular degeneration	Tubular dilatation	Dilated Bowman's space	Protein; casts
Control	0	0	0	0
CoQ10L	0	0	0	0
CoQ10H	++	+	0	0
Dox	+++	++	+	++
Dox/CoQ10L	+	0	0	+
Dox/CoQ10H	+++	++	+	+

CoQ10L and CoQ10H are rat groups treated with low (L) or high (H) dose CoQ10, respectively. Score level 0 was considered normal. Scores +, ++, and +++ are mild, moderate, and severe levels, revealing less than 25, 50, and 75% histopathological alterations of total fields examined, respectively. Score represents values obtained from tissue sections of 3 animals of each group, 5 fields/section (×400).